中药调节肠道微生物治疗慢性间歇性低氧诱发血脂异常的疗效与机制进展

Efficacy and mechanism progress of traditional Chinese medicine by regulating gut microbiota in treating dyslipidemia induced by chronic intermittent hypoxia

慢性间歇性低氧(CIH)是阻塞性睡眠呼吸暂停综合征(OSAS)的核心病理特征,OSAS与血脂异常能协同促进动脉粥样硬化的发生发展。实验研究发现CIH能诱导血脂异常及肠道微生物群紊乱,并且长时间CIH解除后血脂异常和微生物紊乱亦不能完全恢复,临床报道持续气道正压通气不能完全逆转血脂异常,剩余的血脂异常可能与肠道微生物群紊乱未得到完全纠正有关。OSAS合并血脂异常的主要证候属气虚血瘀痰凝,具有益气活血化痰作用的中药可改善呼吸暂停低通气指数,并对肠道微生物产生不同的影响以实现降脂目的,可为治疗OSAS合并血脂异常提供有益补充。

Chronic intermittent hypoxia(CIH)is the core pathological feature of obstructive sleep apnea syndrome(OSAS).OSAS and dyslipidemia can promote the occurrence and development of atherosclerosis.Experimental studies have found that CIH can induce dyslipidemia and gut microbiota disorder,while dyslipidemia and microbiota disorder cannot be completely recovered after a long time of CIH relief.Clinical reports showed that continuous positive airway pressure cannot completely reverse dyslipidemia,suggesting that the remaining dyslipidemia may be related to the gut microbiota disorder that has not been completely corrected.The main syndrome of OSAS complicated with dyslipidemia is qi deficiency,blood stasis and phlegm coagulation.Traditional Chinese medicine with the function of supplementing qi,activating blood circulation and resolving phlegm can effectively improve apnea hypopnea index and have different effects on gut microbiota to achieve the purpose of reducing blood lipid,so as to provide a beneficial supplement for the treatment of OSAS complicated with dyslipidemia.