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针药联合治疗轻度认知功能障碍的临床观察 被引量:5

Clinical observation on the treatment of mild cognitive dysfunction by combination of acupuncture and medicine
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摘要 目的:评价针刺联合多奈哌齐治疗轻度认知功能障碍(MCI)的临床疗效。方法:搜集在2013年3月1日至2016年3月1日诊断为遗忘型的MCI脾肾亏虚证181例住院患者,纳入119例,其中药物组35例(口服多奈哌齐),针药组84例(针刺治疗与口服多奈哌齐)。主要结果是否进展为阿尔茨海默病(AD);次要结果是认知功能测量结果变化。结果:共有19例进展为AD。治疗36个月后,针药组进展为AD较药物组显著降低(P<0.05);认知功能评分简易智力状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、记忆力评分、日常生活能力量表(ADL)评分和临床痴呆量表(CDR)评分较药物组显著改善(P<0.05)。结论:针刺联合多奈哌齐可改善MCI患者的认知功能。 Objective:To evaluate the clinical efficacy of acupuncture combined with donepezil in the treatment of mild cognitive impairment(MCI).Methods:A collection of 181 hospitalized patients with mild cognitive impairment diagnosed with amnestic spleen and kidney deficiency syndrome from March 1,2013 to March 1,2016,included 119 cases,of which 35 cases were in the drug group(oral donepezil),84 patients in the acupuncture group(acupuncture treatment and oral donepezil).Whether the primary outcome has progressed to Alzheimer’s disease(AD);the secondary outcome is changes in cognitive function measurements.Results:A total of 119 patients were effectively evaluated,and 19 patients progressed to AD.After 36 months of treatment,the progression of AD in the acupuncture and medicine group was significantly lower than that in the drug group(P<0.05);the cognitive function scores of the Simple Intelligence Examination Scale(MMSE)score,the Montreal Cognitive Assessment Scale(MoCA)score,and the memory scores,the ability of daily living(ADL)score and the clinical dementia scale(CDR)score were significantly improved compared with the drug group(P<0.05).Conclusion:Acupuncture combined with donepezil can improve the cognitive function of patients with MCI.
作者 梁启放 刘步平 汪峰 李建婷 唐纯志 李嘉烨 张梦阳 陈彬 杨敏 陈思娜 梁敏琴 杨楠 LIANG Qi-fang;LIU Bu-ping;WANG Feng;LI Jian-ting;TANG Chun-zhi;LI Jia-ye;ZHANG Meng-yang;CHEN Bin;YANG Min;CHEN Si-na;LIANG Min-qin;YANG Nan(The First Affiliated Hospital of Guangdong Pharmaceutical University(Clinical School of Medicine),Guangzhou 510080,China;Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Zhongshan Hospital of Traditional Chinese Medicine,Guangdong Province,Guangzhou 528400,China)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2021年第5期3065-3069,共5页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 国家中医药管理局国家中医临床研究基地业务建设科研专项(No.JDZX2015296)。
关键词 针刺 阿尔茨海默病 载脂蛋白E等位基因 血-脑屏障 Acupuncture Alzheimer’s disease APOEε4 Blood-brain barrier
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