疼痛与基因的研究进展

Research progress of pain related genes

随着疼痛研究的不断深入,更多与疼痛相关的基因被发现,这使得人们对疼痛与基因的关系有了更深刻的了解。近年来,人们发现基因多态性,尤其是单核苷酸多态性(single nucleotide polymorphism,SNP)是导致个体疼痛差异的重要原因,而这些差异又与离子通道、神经递质、作用受体以及药物代谢酶等不同层面上的遗传基因密切相关。文章结合离子通道、神经递质基因、作用受体基因以及药物代谢酶基因等内容,探讨基因及其多态性在疼痛发生、发展中的作用,以期为疼痛的治疗与管理提供新思路、新方法。

With the development of pain research,more and more pain related genes have been discovered,and these have led to a deeper understanding of relationships between pain and genes.In recent years,it has been found that gene polymorphism,especially single nucleotide polymorphism(SNP),is an important cause for individual differences in pain.Moreover,these differences are closely related to genes at different levels,such as ion channels,neurotransmitters,action receptors and drug metabolizing enzymes.Combined with the contents of ion channels,neurotransmitter genes,receptor genes and drug metabolizing enzyme genes,the role of genetic polymorphisms in the occurrence and development of pain may be explored.This may also provide new ideas and new methods for the treatment and management of pain.