冠心病患者幽门螺杆菌感染与血管内皮生长因子、基质金属蛋白酶-9和冠脉病变的相关性

Association of helicobacter pylori infection and VEGF,MMP-9 and coronary artery lesions in patients with coronary heart disease

目的探讨冠心病患者幽门螺杆菌(HP)感染与血清中血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)和冠脉病变的相关性。方法选取自2014年1月至2019年6月在我院住院诊治的冠心病患者160例研究对象,按HP感染情况分为2组:HP阴性组(n=59)和HP感染组(n=101)。HP感染组按感染程度又分为HP轻度感染组(n=63)和HP重度感染组(n=38)。采用病例对照研究方法,进行单因素分析,多因素分析和相关性分析,分析HP感染的相关因素及其关联强度。结果冠心病患者中,单因素分析HP感染组VEGF和MMP-9表达水平及Gensini评分显著高于HP阴性组(P<0.01);与HP轻度感染组相比较,HP重度感染组VEGF和MMP-9表达水平及Gensini评分较高(P<0.05);HP感染独立相关因素是血清VEGF、MMP-9和Gensini积分,均呈正相关(P<0.05)。结论冠心病患者HP感染与VEGF、MMP-9和Gensini积分呈正相关。

AIM To investigate the relationship between Helicobacter pylori(HP)infection and serum vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9)and coronary artery disease in patients with coronary heart disease.METHODS From January 2014 to June 2019,160 patients with coronary heart disease were selected and divided into two groups according to HP infection:HP negative group(n=59)and HP infection group(n=101).HP infection group was divided into mild HP infection group(n=63)and severe HP infection group(n=38).Case control study was used to analyze the related factors of HP infection and its correlation strength by univariate analysis,multivariate analysis and correlation analysis.RESULTS In CHD,the expression levels of VEGF and MMP-9 and Gensini score in HP infection group were significantly higher than those in HP negative group(P<0.01);compared with mild HP infection group,VEGF and MMP-9 expression level and Gensini score in severe HP infection group were significantly higher(P<0.05);and the level of serum VEGF,MMP-9 and Gensini score were positively correlated with HP infection(P<0.05).CONCLUSION HP infection is positively correlated with VEGF,MMP-9 and Gensini score in patients with coronary heart disease.