摘要
ADAM17又称TNF-α转化酶(TNF-αconverting enzyme,TACE)是一种去整合素-金属蛋白酶(a disintegrin and metalloproteases,ADAMs),通过对膜蛋白进行切割、使胞外片段从细胞膜表面脱落而调控细胞对外界刺激反应,也被称为细胞中的“分子剪刀”。ADAM17介导膜蛋白表皮生长因子受体(epidermal growth factor receptor,EGFR)配体、TNF-α、ICAM-1、VCAM-1、ACE2、VEGFR2等切割脱落,激活或阻断相关细胞信号通路,参与冠心病、动脉瘤、心力衰竭、高血压等心血管疾病过程,未来可能成为心血管疾病的防治靶点。
ADAM17,also known as TNF-αconverting enzyme(TACE),is a member of a disintegrin and metalloproteases(ADAMs)family,which cuts off the ectodomain of membrane proteins and then regulates the cell’s responsiveness to external stimuli.It is called"molecular scissors"based on its important roles in multiple cell processes.ADAM17 mediates the cleavage of EGFR ligands,TNF-α,ICAM-1,VCAM-1,ACE2 and VEGFR2,thus participating in the pathological process of many cardiovascular diseases and adverse events such as coronary heart disease,aneurysm,heart failure and hypertension.ADAM17 may be a promising target for the prevention and treatment of cardiovascular diseases in the future.
作者
成雅
王海芳
袁瑞华
董静
刘勤社
CHENG Ya;WANG Hai-fang;YUAN Rui-hua;DONG Jing;LIU Qin-she(Shaanxi and Xianyang Key Laboratory of Integrated Traditional and Western Medicine for Prevention and Treatment of Cardiovascular Diseases,Xi’an 712046,Shaanxi,China;Real World Clinical Research Institute,Shaanxi University of Traditional Chinese Medicine,Xi’an 712046,Shaanxi,China;Department of Cardiology,Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xi’an 712000,Shaanxi,China)
出处
《心脏杂志》
CAS
2021年第2期199-204,共6页
Chinese Heart Journal
基金
国家自然科学基金项目资助(81573823)
陕西省中医管理局项目资助(2019-ZZ-JC025)
陕西中医药大学第二附属医院学科创新团队项目资助(2020XKTD-B02)。
关键词
去整合素-金属蛋白酶17
肿瘤坏死因子-Α
表皮生长因子受体
炎症
心血管不良事件
a disintegrin and metalloproteinase 17
tumor necrosis factor-α
epidermal growth factor receptor
immune-inflammation
cardiovascular adverse events
