运动诱导的microRNA与心肌梗死的研究进展

Research progress in exercise-induced microRNAs and myocardial infarction

运动使心血管系统获益众多,目前已将运动作为心肌梗死的重要治疗措施之一。由于运动调节心肌梗死(MI)的复杂性,其具体机制仍未完全阐明。近年来发现运动过程中多种微小RNAs(microRNAs,miRNAs)的表达发生改变,并且进一步发现运动诱导的miRNAs在MI病程中发挥重要作用。因此,本文重点总结基于运动调控下对于MI产生调节作用的miRNAs并分析其可能机制,旨在为运动训练对心肌梗死的临床应用提供更深入的理论依据。

Exercise brings multiple benefits for cardiovascular system and it has been recommended as one of the therapeutic approaches for myocardial infarction.Owing to the complexity of exercise in regulating myocardial infarction,its specific mechanism has not been fully elucidated.Recently,it has been found that the expressions of a variety of miRNAs have changed during exercise and it has been further found that exercise-induced miRNAs play an important role in the course of myocardial infarction.Therefore,this article focuses on summarizing the regulatory effect of miRNAs on myocardial infarction under exercise regulation and analyzing its possible mechanism,in order to provide a more indepth theoretical basis for the clinical application of exercise training for myocardial infarction.