内皮细胞代谢调控在血管性疾病中的研究进展

Recent advances of endothelial metabolism in vascular diseases

内皮细胞(endothelial cell,EC)代谢在机体正常发育和疾病发生中发挥着重要作用。与其他类型细胞相比,EC高度依赖糖酵解、脂肪酸氧化和氨基酸代谢等,以使其具备将血液中氧气和营养物质运输至周围组织以及在乏氧无血管区域进行血管生成的能力。随着研究深入,越来越多代谢途径被发现参与调控EC增殖、迁移和血管生成等过程。异常的内皮细胞代谢导致EC增殖、迁移以及血管生成等能力丧失或增强,进而引发动脉粥样硬化、心肌梗死、肢体缺血等血管性疾病发生,靶向EC代谢方式是血管性疾病的潜在治疗靶点。本文就EC代谢调控在血管性疾病中作用的研究进展进行阐述,以期为血管性疾病的防治提供新思路。

Endothelial cell(EC)plays an important role in health and disease.Compared with other cell types,EC is highly dependent on glycolysis,fatty acid oxidation and amino acid metabolism,in order to efficiently transport oxygen and nutrients from blood to surrounding tissues and form new vessels in hypoxia avascular areas.With the in-depth study,metabolic pathways have been reported to be involved in regulating EC proliferation,migration and angiogenesis.Abnormal regulation of EC metabolism leads to the loss or enhancement of EC proliferation,migration and angiogenesis,and finally results in vascular diseases including atherosclerosis,myocardial infarction,and limb ischemia.Thus metabolic pathways may be regarded as potential therapeutic targets.This article reviews the research progress of metabolism regulation in EC in vascular diseases,in order to provide novel ideas for the prevention and treatment of vascular diseases in the future.