血小板参数与丙肝病毒复制严重程度的关系

The relationship between platelet parameters and the severity of hepatitis C virus replication

目的探讨血小板参数在丙肝病毒(HCV)复制严重程度评价中的应用价值。方法选取2017年1月-2019年5月本院收治的90例丙肝患者,测定HCV-RNA载量,统计HCV-RNA复制程度。所有患者均检测血小板参数[血小板计数(PLT)及血小板平均体积(MPV)],使用受试者工作曲线(ROC)的曲线下面积(AUC)评价血小板参数评价HCV复制严重程度的价值。结果 90例患者中HCV-RNA阴性65例,HCV-RNA阳性25例;HCV-RNA阴性、阳性患者性别、年龄、病程、体重比较,差异无统计学意义(P>0.05);HCV-RNA阴性患者PLT水平高于HCV-RNA阳性患者,MPV水平低于HCV-RNA阳性患者,差异有统计学意义(P<0.05)。ROC曲线结果显示PLT、MPV评估HCV复制程度的AUC为0.857、0.829。结论 PLT、MPV能有效评估HCV复制严重程度。

Objective To explore the application value of platelet parameters in the evaluation of the severity of hepatitis C virus(HCV)replication.Methods A total of 90 HCVpatients admitted to our hospital from January 2017 to May2019 were selected.The HCV-RNA load were measured and the HCV-RNA replication were counted.All patients were tested for platelet parameters[platelet count(PLT)and mean platelet volume(MPV)].The area under the curve(AUC)of the receiver operating curve(ROC)was used to evaluate the severity of HCV replication.Results 65 patients were negative for HCV-RNA and 25 patients were positive for HCV-RNA.There was no significant difference in gender,age,course of disease and weight betweenHCV-RNA negative patients and positive patients(P>0.05).The PLT level of HCVRNA negative patients was higher than that of HCV-RNA positive patients,the MPV level was lower than that of HCVRNA positive patients,the difference was statistically significant(P<0.05).ROC curve results showed that the AUC of PLT and MPV to assess the degree of HCV replication were 0.857 and 0.829.Conclusion PLT and MPV can effectively assess the severity of HCV replication.