联合用药对迁延性腹泻的疗效

The efficacy of combined medication in the treatment of persistent diarrhea

目的分析葡萄糖酸锌口服液联合布拉氏酵母散治疗迁延性腹泻的效果。方法将我院收收治的102例迁延性腹泻患儿依据不同治疗方案分为两组,每组51例。对照组接受布拉氏酵母散治疗,观察组接受葡萄糖酸锌口服液联合布拉氏酵母散治疗,两组持续治疗7 d,比较两组疗效、不良反应、退热时间、大便性状复常时间、大便次数复常时间及治疗前后血清T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、氧化应激[一氧化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)]水平。结果观察组有效率高于对照组(P<0.05);观察组大便性状复常时间、大便次数复常时间、退热时间短于对照组(P<0.05);治疗后观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05);治疗3 d、7 d观察组NO、MDA少于对照组,SOD高于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论葡萄糖酸锌口服液联合布拉氏酵母散治疗迁延性腹泻患儿效果显著,可减轻临床症状,提高免疫力,调节氧化应激,并减少不良反应的发生。

Objective To analyze the efficacy of zinc gluconate oral liquid combined with saccharomyces boulardii sachetsin the treatment of persistent diarrhea.Methods A total of 102 children with persistent diarrhea admitted in our hospital were divided into two groups according to treatment plans,51 cases in each group.The control group received saccharomyces boulardii sachets,and the observation group received zinc gluconate oral liquidon the basis of the control group.The two groups received continuous treatment for 7 days.The efficacy,adverse reactions,antipyretic time,fecal characteristics recovery time,fecal frequency recovery time and the levels of serum T lymphocyte subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)),oxidative stress[nitric oxide(NO),superoxide dismutase(SOD),malondialdehyde(MDA)]before and after treatment were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group(P<0.05).The fecal characteristics recovery time,fecal frequency recovery time and antipyretic time in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher than those in the control group(P<0.05).the levels of NO and MDA in the observation group were lower than those of the control group on the 3 rd and 7 th day of treatment,and SOD was higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that of the control group(P<0.05).Conclusion Zinc gluconate oral liquid combined with saccharomyces boulardii sachets is effective in treating children with persistent diarrhea,which can relieve clinical symptoms,improve immunity,regulate oxidative stress,and reduce adverse reactions.