冠状动脉斑块CT血管造影征象与血清RANTES水平的相关性研究

Study on the correlation between CTA signs of coronary plaque and serum RANTES level

目的探讨冠状动脉斑块CT血管造影(CTA)征象与血清活化T细胞趋化因子(RANTES)水平的相关性。方法选取2017年1-12月于该院收治的冠心病患者226例作为观察组,均经过冠状动脉造影及超声心动图确诊。根据获得的冠状动脉斑块CT值不同将患者分为非钙化斑块组(68例),混合斑块组(73例)及钙化斑块组(85例)。另选取同期体检健康者80例作为对照组。收集研究对象一般资料及冠状动脉狭窄程度Gensini积分,采用酶联免疫吸附试验(ELISA)法检测各组血清RANTES水平。采用Pearson相关分析冠心病患者粥样斑块CT值与血清RANTES水平的相关性。结果观察组收缩压、舒张压、总胆固醇、低密度脂蛋白、三酰甘油、血清RANTES水平高于对照组,差异均有统计学意义(P<0.05)。非钙化斑块组、混合斑块组及钙化斑块组CT值依次升高(P<0.05),Gensini积分、血清RANTES水平依次降低(P<0.05)。Pearson相关分析结果显示,冠心病患者粥样斑块CT值与血清RANTES水平呈负相关(r=-0.720,P<0.05)。经Kaplan-Meier生存分析可知,CT高值组生存率高于CT低值组,血清RANTES高表达组生存率高于血清RANTES低表达组。结论冠心病患者冠状动脉斑块CTA征象反映的斑块性质与血清RANTES水平密切相关,二者对判断冠状动脉斑块具有较好的辅助诊断价值。

Objective To investigate the correlation between CT angiography(CTA)signs of coronary plaque and serum regulated upon activation normal T cell expressed and secreted(RANTES)level.Methods A total of 226 patients with coronary heart disease admitted to a hospital from January to December 2017 were selected as the observation group,all of whom were confirmed by coronary angiography and echocardiography.According to the obtained CT value of coronary plaque,the patients were divided into non calcified plaque group(68 cases),mixed plaque group(73 cases)and calcified plaque group(85 cases).In addition,80 healthy people in the same period were selected as the control group.The general data of patients and Gensini score of coronary stenosis were collected,and the serum RANTES level was detected by enzyme-linked immunosorbent assay(ELISA).Pearson analysis was used to analyze the correlation between the CT value of atherosclerotic plaque and the level of RANTES in serum.Results The levels of systolic blood pressure,diastolic blood pressure,TC,LDL,TG and serum RANTES level in the observation group were all higher than those in control group,with statistical significance(P<0.05).The CT value of non calcified plaque group,mixed plaque group and calcified plaque group increased in turn(P<0.05),and the Gensini integral and serum RANTES level decreased in turn(P<0.05).Pearson analysis showed that there was a negative correlation between the CT value of atherosclerotic plaque and the serum RANTES level(r=-0.720,P<0.05).According to Kaplan-Meier survival analysis,the survival rate of patients with high CT values was higher than that of patients with low CT values;the survival rate of patients with high serum RANTES expression group was higher than that of patients with low serum RANTES expression group.Conclusion The plaque properties of CTA signs in coronary plaques in patients with coronary heart disease are closely related to serum RANTES level,and both of them have good auxiliary diagnostic value in the diagnosis of coronary plaques.