水通道蛋白在ADPKD中的研究现状与进展

Research progress of aquaporins in autosomal dominant polycystic kidney disease

常染色体显性遗传性多囊肾病(ADPKD)是一种以双侧肾脏弥漫进行性囊肿形成为主要表现的遗传性肾病,囊肿压迫并损害肾实质,最终导致肾功能衰竭。水通道蛋白广泛分布于机体多种组织中,可以调节水和一些溶质在细胞内外的跨膜运输,在人类健康和疾病中扮演着重要角色。目前已发现一些水通道蛋白包括AQP1、AQP2、AQP3和AQP11,与ADPKD关系密切,可能通过多种信号通路参与调控囊肿形成,本文将综述水通道蛋白成员在ADPKD中的分子作用机制,为ADPKD的治疗探索新的潜在靶点。

Autosomal dominant polycystic kidney disease(ADPKD)is one of the most common inherited kidney diseases characterized by diffuse and progressive cyst formation in bilateral kidneys.The cyst compresses and damages renal parenchyma,eventually leading to renal failure.Aquaporins are widely distributed in various tissues of the body,regulating the transmembrane transport of water and some solutes and playing an important role in human health and disease.It has been reported that some aquaporins including AQP1,AQP2,AQP3 and AQP11 are closely related to ADPKD and may participate in the regulation of cyst formation through a variety of signaling pathways.This article will review the molecular mechanism of aquaporins in ADPKD,so as to explore new potential targets in its treatment.