剪切波频散成像技术评价正常兔肝消融后炎症反应带的实验研究

Experimental study of shear wave dispersion imaging in evaluating inflammatory reaction zone after ablation in normal rabbit liver

目的评价剪切波频散成像技术在鉴别兔肝消融后炎症反应带中的应用价值。方法制作兔正常肝组织激光消融模型,在消融后3 d、7 d、14 d对消融灶进行剪切波频散成像及应变弹性成像检查。观察消融后中央坏死组织、周围炎症反应带及正常肝组织的剪切波弹性值、频散值及弹性应变比值差异。结果兔肝消融灶炎症反应带、中央坏死组织及正常肝组织剪切波频散值分别为(26.07±4.55)m·s^(-1)·kHz^(-1)、(21.97±10.53)m·s^(-1)·kHz^(-1)及(15.45±3.94)m·s^(-1)·kHz^(-1),差异有统计学意义(均P<0.05)。消融术后3 d、7 d、14 d这3个时间段比较,术后7 d炎症区剪切波频散值最高(P<0.05),而该区域弹性值及应变比值在这3个时间段无明显变化(均P>0.05)。结论剪切波频散成像技术可同步测量组织的弹性及黏性,对识别兔肝消融后炎症反应带有一定应用价值。

Objective To evaluate the value of shear wave dispersion imaging in identifying inflammatory reaction zone after liver ablation in rabbits.Methods The animal model was made by laser ablation of rabbit liver,and then shear wave dispersion imaging and strain elastography imaging were performed on the ablation area at 3 d,7 d,and 14 d after ablation.The shear wave dispersion values,elastic value and strain ratio measured by shear wave elastography,shear wave dispersion and strain elastography in different regions such as central necrotic tissue,surrounding inflammatory reaction zone and normal liver tissue after ablation were analyzed.Results The shear wave dispersion values of inflammatory reaction zone around ablation site,necrotic tissue in the center of ablation site and normal liver tissue in rabbits were(26.07±4.55)m·s^(-1)·kHz^(-1),(21.97±10.53)m·s^(-1)·kHz^(-1)and(15.45±3.94)m·s^(-1)·kHz^(-1),respectively,the differences were statistically significant(all P<0.05).Compared with the three time points of 3 d,7 d and 14 d after ablation,the shear wave dispersion value of the inflammatory zone was the highest on the 7th day after ablation(P<0.05),while the elastic value and strain ratio in this region did not change significantly among these three time points(P>0.05).Conclusions Shear wave dispersion imaging can simultaneously measure tissue elasticity and viscosity,which has certain application value in identifying the inflammatory reaction zone around the ablation site in rabbit liver.