靳三针联合百乐眠胶囊治疗围绝经期失眠肝郁阴虚证的疗效观察

Jin’s Three-Needle combined with Bailemian Capsule for perimenopausal insomnia of liver depression and yin deficiency

目的探讨靳三针联合百乐眠胶囊治疗围绝经期失眠肝郁阴虚证的临床疗效。方法选取2018年6月—2020年5月北京市垂杨柳医院收治的80例围绝经期失眠肝郁阴虚证患者,随机分成治疗组和对照组各40例。对照组予百乐眠胶囊进行治疗,治疗组在对照组基础上加靳三针治疗,2组均连续治疗6周。评价治疗3周后及治疗6周结束后的临床疗效;观察治疗前、治疗3周后及治疗6周结束后的匹兹堡睡眠质量指数(PSQI)评分,对患者睡眠质量进行评价。结果治疗组治疗3周后及6周后的总有效率分别为72.50%和92.50%,明显高于对照组的57.50%和82.50%,差异有统计学意义(P<0.05);治疗3周后和6周后,2组患者PSQI各维度得分及总分均低于治疗前,且治疗组患者在治疗3周后与6周后PSQI各维度得分及总分均显著低于对照组,差异均有统计学意义(P<0.05);治疗期间,2组均未见明显不良反应,未见血、尿、大便常规化验异常及肝肾功能异常,安全性良好。结论采用靳三针联合百乐眠胶囊治疗围绝经期失眠肝郁阴虚证可明显提高临床疗效,缩短疗程,提高患者满意度及依从性,且安全性良好。

Objective To investigate the clinical efficacy of Jin’s Three-Needle combined with Bailemian Capsule in the treatment of perimenopausal insomnia of the liver depression and yin deficiency type. Methods From June 2018 to May 2020, 80 cases of perimenopausal insomnia with the type of liver depression and yin deficiency were randomly assigned to the treatment group and control group, with 40 cases in each group. The control group was treated with Bailemian Capsule, while the treatment group received additional treatment of Jin’s Three-Needle. Both groups were treated for 6 weeks.The clinical efficacy was evaluated 3 weeks and 6 weeks after treatment. The Pittsburgh sleep quality index(PSQI) scores before treatment, 3 weeks after treatment and 6 weeks after treatment were observed to evaluate the sleep quality of the patients. Results The total effective rates of the treatment group at 3 weeks and 6 weeks after treatment, which were 72.50% and 92.50%, were significantly higher than those of the control group, which were 57.50% and 82.50%, and the difference was statistically significant(P< 0.05). At 3 weeks and 6 weeks after treatment, the scores and total scores of PSQI in the two groups were lower than those before treatment, and the scores and total scores of PSQI in the treatment group at 3 weeks and 6 weeks after treatment were significantly lower than those in the control group(all P< 0.05). During the treatment, there were no obvious adverse reactions, no abnormal blood, urine, stool routine tests and abnormal liver and kidney functions in both groups, with good safety. Conclusions Jin’s Three-Needle combined with Bailemian Capsule in the treatment of perimenopausal insomnia of liver depression and yin deficiency can significantly improve the clinical efficacy, shorten the course of treatment, improve patient satisfaction and compliance, and it has good safety.