2017~2019年某院脓毒血症患者原菌菌种鉴定及药敏试验结果分析

Identification of pathogenic bacteria and analysis of drug sensitivity test results in patients with sepsis in a hospital from 2017 to 2019

目的分析2017~2019年葫芦岛市中心医院脓毒血症患者病原菌菌种及药敏情况。方法选取2017年1月~2019年12月葫芦岛市中心医院收治的896例脓毒血症患者,对其静脉血培养分离的386株病原菌进行菌种鉴定及药敏试验检测。结果386株病原菌中,产碱杆菌、黏质沙雷菌、伯克霍尔德菌、假单胞菌、嗜麦芽窄食单胞菌以及凝固酶阴性葡萄球菌为占比最高的6种;149株革兰氏阳性球菌对红霉素、克林霉素、青霉素、苯唑西林等耐药率较高,对替加环素、利奈唑胺、万古霉素、利福平等敏感;230株革兰氏阴性杆菌对多黏菌素B、氨曲南等耐药率较高,对亚胺培南、头孢哌酮、米诺环素、复方新诺明、头孢吡肟、头孢他啶等敏感。结论通过对脓毒血症患者静脉血培养分离处的菌株进行鉴定得出,主要病原菌菌种为产碱杆菌、黏质沙雷菌、伯克霍尔德菌、假单胞菌、嗜麦芽窄食单胞菌、凝固酶阴性葡萄球菌等,菌种种类较多,不同的菌株耐药情况也不同,总体对复方新诺明、亚胺培南、头孢吡肟、头孢他啶、替加环素、万古霉素、利福平等敏感。

Objective To analyze the pathogen identification and drug sensitivity test results of sepsis patients in Huludao Central Hospital from 2017 to 2019.Methods A total of 896 patients with sepsis admitted to Huludao Central Hospital from January 2017 to December 2019 were selected,and 386 strains of pathogenic bacteria isolated from their venous blood culture were identified and drug sensitivity test detected.Results Among the 386 strains of pathogenic bacteria,Alkalobacter,Serrata marcescens,Burkholderia,Pseudomonas,Stenotrophomonas maltophilia and coagulase-negative Staphylococcus were the six species with the highest proportion.The 149 Gram-positive cocci showed higher resistance rates to Erythromycin,Clindamycin,Penicillin and Oxacillin,and were sensitive to Tegacycline,Linezolid,Vancomycin and Rifamequin.The 230 Gram-negative bacilli showed high drug resistance to Polymyxin B and Amtronam,and were sensitive to Imipenem,Cefoperazone,Minoccyccline,Cotrimoxazole,Cefepime,Ceftazidime,etc.Conclusion By identifying strains from the venous blood culture isolates of sepsis patients,the main pathogenic bacteria were Alkalogenic bacilli,Serrata marcescens,Burkholderia,Pseudomonas,Stenotrophomonas maltophilia,coagulase-negative Staphylococcus.There were many species of strains,and drug resistance of different strains was also different.Generally,the strains were sensitive to Cotrimoxazole,Imipenem,Cefepime,Ceftazidime,Tigacycline,Vancomycin and Rifamequin.