穴位贴敷疗法防治小儿支气管哮喘用药取穴规律及疗效影响因素分析

Analysis of Medication Regularity and Influencing Factors of Therapeutic Effect of Acupoint Application Therapy in the Prevention and Treatment of Bronchial Asthma in Children

目的:通过分析穴位贴敷疗法防治小儿支气管哮喘的文献,探讨其用药规律及影响临床疗效的相关因素。方法:使用中国生物医学服务系统检索中国期刊全文数据库、中国生物医学数据库、万方期刊数据库、维普数据库、中国医学科普文献数据库。使用Excel表对频数、穴位选取、组方、调和物质及时节选择等数据进行统计分析,采用中国中医科学院中医传承辅助系统软件进行处方用药模式分析。结果:检索到文献164篇,纳入103篇。药物频数排名前5的依次是:芥子(102)、细辛(93)、甘遂(78)、延胡索(77)、麝香(23)。对芥子、细辛、甘遂、延胡索的比例分析,2∶1∶1∶2的药物配比频率最高。调和药物的物质使用前3位分别是姜汁(61)、醋(12)、麻油(10)。选用频数前10的腧穴分别为肺俞、膏肓、定喘、膈俞、心俞、膻中、肾俞、脾俞、大椎、百劳。时节的选择频数最高的是三伏,为89篇。基于Apriori算法进行关联分析,处方中出现频率及支持度较高的药物配伍模式为“芥子、延胡索、细辛、甘遂”配伍模式。当支持度为30%时,形成以“芥子-延胡索-细辛-甘遂”的最核心的本质药物组方模式。结论:从多个角度分析了可能影响穴位贴敷防治小儿支气管哮喘疗效的因素,为穴位贴敷防治小儿支气管哮喘规范化研究提供了部分参考依据。

Objective:To analyze the literature of acupoint application therapy in the prevention and treatment of bronchial asthma in children,and to explore its medication rules and related factors affecting clinical therapy.Methods:the Chinese Biomedical service system developed by the library of Chinese Academy of Medical Sciences was used to search Chinese journal full text database,Chinese biomedical database,Wanfang journal database,VIP database and Chinese medical popular science literature database.Excel table was used to analyze the data of frequency,acupoint selection,prescription,reconciliation substance and season selection,and traditional Chinese Medicine Inheritance assistant system software was used to analyze the prescription medication mode.Results:A total of 164 articles were retrieved,and 103 articles were included in the final statistics.Among the 103 literatures,the top five drugs were mustard seed(Brassicae Junceae Semen)(102),asarum(Asari Herba)(93),kansui(Kansui Radix)(78),corydalis(Corydalis Rhizoma)(77),musk(Moschus)(23).For the proportion analysis of mustard seed,asarum,kansui and corydalis,the ratio of 2:1:1:2 was the highest.Ginger juice(61),vinegar(12)and sesame oil(10)were the top three in the use of concordant drugs.The top 10 acupoints were Feishu(BL13),Gaohuang(BL43),Dingchuan(EXB1),Geshu(BL17),Xinshu(BL15),Danzhong(CV17),Shenshu(BL23),Pishu(BL20),Dazhui(GV14)and Bailao(GV14).The frequency of season selection was the highest in Sanfu,which had 89 articles.Based on Apriori algorithm for association analysis,the drug compatibility mode with high frequency and support in prescription was"mustard seed,yanhusuo,asarum,kansui".The result of complex system entropy clustering network mapping using traditional Chinese Medicine Inheritance assistant platform shows that when the support degree is 30%,the core essential medicine prescription mode of"Mustard yanhusuo Asarum kansui"was formed.Conclusion:The factors that may affect the therapeutic effect of Acupoint Application in the prevention and treatment of bronchial asthma in children are analyzed from multiple perspectives,which provides some reference for the standardized study of Acupoint Application in the prevention and treatment of bronchial asthma in children.