正念疗法联合利培酮用于康复期精神分裂症患者情感障碍的效果观察

Mindfulness-based therapy combined with risperidone treatment for emotional disorder in schizophrenic patients during the recovery period

目的探讨正念疗法联合利培酮用于康复期精神分裂症患者情感障碍的临床效果。方法选取金华市第二医院2017年3月至2019年2月收治的康复期精神分裂患者106为研究对象,采用随机数字表法分为研究组53例、对照组53例。对照组患者给予利培酮治疗,研究组患者在对照组治疗的基础上实施正念训练。比较两组患者治疗前后阳性与阴性症状量表(PANSS)评分和社会功能评定量表(SSPI)评分。结果治疗前,两组PANSS总分、阴性症状、阳性症状及精神病理项目评分差异均无统计学意义(均P>0.05);治疗后,研究组阴性症状、阳性症状、精神病理及PANSS总分分别为(11.54±1.63)分、(11.56±1.61)分、(21.71±1.85)分、(44.66±3.01)分,对照组分别为(15.31±1.91)分、(15.29±1.89)分、(23.51±2.11)分、(52.06±3.32)分,两组均低于治疗前(研究组:t=10.352、10.337、8.419、15.630,对照组:t=2.607、2.601、4.534、7.131,均P<0.05),且研究组均低于对照组(t=10.930、10.937、4.670、12.022,均P<0.05)。治疗前,两组患者日常生活能力、社会性活动技能、始动性和交往情况评分差异均无统计学意义(均P>0.05);治疗后,研究组社会性活动技能、日常生活能力、始动性和交往情况评分分别为(12.88±1.62)分、(10.58±1.54)分、(13.14±1.97)分,对照组分别为(11.92±1.56)分、(9.01±1.43)分、(11.46±1.69)分,两组均较治疗前明显升高(研究组:t=6.783、5.475、4.430,对照组:t=3.956、2.263、2.009,均P<0.05),且研究组均高于对照组(t=3.108、5.439、4.712,均P<0.05)。结论对康复期精神分裂症患者采用正念疗法联合利培酮治疗,可有效改善情感障碍及精神分裂症状,提高患者社会功能。

Objective To investigate the clinical effect of mindfulness-based therapy combined with risperidone treatment on emotional disorder in schizophrenic patients during the recovery period.Methods A total of 106 schizophrenic patients during the recovery period who received treatment from March 2017 to February 2019 in The Second Hospital of Jinhua,China were included in this study.They were randomly assigned to undergo mindfulness-based therapy combined with risperidone treatment alone(study group,n=53)or risperidone treatment(control group,n=53).The Positive and Negative Syndrome Scale(PANSS)score and Scale of Social Function in Psychosis Inpatients(SSPI)score were compared between study and control groups before and after treatment.Results Before treatment,there were no significant differences in PANSS total score,negative scale score,positive scale score,general psychopathology scale score between study and control groups(all P>0.05).After treatment,negative scale score,positive scale score,general psychopathology scale score and PANSS total score in the study group were(11.54±1.63)points,(11.56±1.61)points,(21.71±1.85)points,(44.66±3.01)points respectively,and they were(15.31±1.91)points,(15.29±1.89)points,(23.51±2.11)points,(52.06±3.32)points,respectively in the control group.After treatment,negative scale score,positive scale score,general psychopathology scale score and PANSS total score in each group were significantly lower than those before treatment(study group:t=10.352,10.337,8.419,15.630;control group:t=2.607,2.601,4.534,7.131,all P<0.05).After treatment,negative scale score,positive scale score,general psychopathology scale score and PANSS total score in the study group were significantly lower than those in the control group(t=10.930,10.937,4.670,12.022,all P<0.05).Before treatment,there were no significant differences in scores of activities of daily living,social skills and initiative and communication between the two groups(all P>0.05).After treatment,scores of social skills,activities of daily living and initiative and communication in the study group were(12.88±1.62)points,(10.58±1.54)points,(13.14±1.97)points respectively,and they were(11.92±1.56)points,(9.01±1.43)points,and(11.46±1.69)points respectively in the control group.After treatment,scores of social skills,activities of daily living and initiative and communication in each group were significantly higher than those before treatment(study group:t=6.783,5.475,4.430;control group:t=3.956,2.263,2.009,all P<0.05).After treatment,scores of social skills,activities of daily living and initiative and communication in the study group were significantly higher than those in the control group(t=3.108,5.439,4.712,all P<0.05).Conclusion Mindfulness-based therapy combined with risperidone treatment for emotional disorder in schizophrenic patients during the recovery period can effectively improve the emotional disorder,reduce the schizophrenia symptoms,and improve the social function of patients.