维生素A水平与儿童社区获得性肺炎的相关性研究

Correlation between Vitamin A Levels and Community-Acquired Pneumonia in Children

目的探讨维生素A(VA)水平与儿童社区获得性肺炎(CAP)严重程度及肺炎支原体(MP)感染的相关性,从而为儿童CAP的防治以及病情的评估提供参考依据。方法随机选取155例因CAP住院的≤5岁患儿作为研究对象,分别将其按照病情严重程度以及是否存在MP感染进行分组,比较各组间的VA水平。结果155例CAP患儿VA平均水平为0.19±0.06mg/L;其中轻症肺炎组VA水平高于重症肺炎组,重症肺炎组临床型VA缺乏(CVAD)、亚临床型VA缺乏(SVAD)检出率均明显高于轻症肺炎组,轻症肺炎组边缘型VA缺乏(MVAD)检出率高于重症肺炎组,差异均有统计学意义(P<0.05);MP阴性组VA水平高于MP阳性组,MP阳性组SVAD检出率高于MP阴性组,MP阴性组MVAD检出率高于MP阳性组,差异均有统计学意义(P<0.05);VA水平与CAP严重程度和MP感染之间存在相关性。结论VA水平与儿童CAP严重程度有关,MP感染会进一步降低CAP患儿体内VA水平。

Objective To investigate the correlation between vitamin A(VA) levels and the severity of communityacquired pneumonia(CAP) and mycoplasma pneumoniae(MP) infection in children, thus to provide reference for the prevention and treatment of CAP in children and the assessment of the disease. Methods A total of 155 children≤5 years old, who were hospitalized due to CAP, were randomly selected as study subjects. Patients were divided into groups according to the severity of the disease and the presence or absence of MP infection, and the serum VA levels were compared between the groups. Results The average VA level of 155 children with CAP was 0.19±0.06 mg/L. The VA level in the mild pneumonia group was higher than that in the severe pneumonia group, the detection rates of clinical type VA deficiency(CVAD) and subclinical type VA deficiency(SVAD) in the severe pneumonia group were significantly higher than that in the mild pneumonia group, and the detection rates of marginal type VA deficiency(MVAD) in the mild pneumonia group were higher than that in the severe pneumonia group, with statistically significant differences(P<0.05). The VA level of the MP negative group was higher than that of the MP positive group, the detection rate of SVAD in the MP positive group was higher than that of the MP negative group, and the detection rate of MVAD in the MP negative group was higher than that of the MP positive group, with statistically significant differences(P<0.05). VA levels were associated with CAP severity and MP infection. Conclusion The VA level is related to the severity of CAP in children, and MP infection will further reduce the VA level in children with CAP.