气管镜联合氨溴索治疗卒中相关性肺炎的临床分析

Clinical analysis of bronchoscopy combined with ambroxol in the treatment of stroke-related pneumonia

目的探析卒中相关性肺炎患者应用气管镜联合氨溴索治疗的效果。方法选取2018年7月至2019年12月本院收治的54例卒中相关性肺炎患者作为研究对象,随机分为对照组与实验组,每组27例。对照组予以常规治疗,实验组在对照组基础上予以气管镜联合氨溴索治疗,比较两组临床疗效、临床指标水平、症状消失时间、APACHEⅡ评分及不良反应发生率。结果实验组治疗总有效率为96.30%,明显高于对照组的77.78%,差异有统计学意义(P<0.05)。治疗前,两组WBC、CRP、PCT水平比较差异无统计学意义;治疗后,实验组WBC、CRP、PCT水平均低于对照组,差异有统计学意义(P<0.05)。实验组咳痰、发热、气喘、胸片阴影消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组APACHEⅡ评分比较差异无统计学意义;治疗后,实验组APACHEⅡ评分低于对照组,差异有统计学意义(P<0.05)。实验组不良反应发生率为7.41%,对照组为3.70%,两组比较差异无统计学意义。结论卒中相关性肺炎患者应用气管镜联合氨溴索治疗效果确切,不仅可改善患者临床症状,减轻炎症反应,且未明显不增加不良反应,值得临床推广应用。

Objective To explore the effect of bronchoscopy combined with ambroxol in patients with stroke-related pneumonia.Methods 54 stroke-related pneumonia patients admitted to our hospital from July 2018 to December 2019 were selected as the research subjects,and they were randomly divided into control group and experimental group,with 27 cases in each group.The control group received conventional treatment,and the experimental group received bronchoscopy combined with ambroxol treatment on the basis of the control group.The clinical efficacy,clinical index levels,symptom disappearance time,APACHEⅡscore,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 96.30%,which was significantly higher than 77.78%in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of WBC,CRP and PCT between the two groups;after treatment,the levels of WBC,CRP and PCT in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.05).The disappearance time of sputum expectoration,fever,asthma,and chest radiograph shadow in the experimental group was shorter than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in APACHEⅡscore between the two groups;after treatment,the APACHEⅡscore of the experimental group were lower than the control group,the difference was statistically significant(P<0.05).The adverse reaction rate was 7.41%in the experimental group and 3.70%in the control group,there was no statistically significant difference between the two groups.Conclusion The treatment effect of bronchoscopy combined with ambroxol in patients with stroke-related pneumonia is definite.It can not only improve patients’clinical symptoms and reduce inflammation,but also does not significantly increase adverse reactions.It is worthy of clinical application.