Gas6与子痫前期的相关性研究

Study on the Correlation between Growth Arrest-Specific 6 and Pre-eclampsia

目的探究Growth Arrest-Specific 6(Gas6)水平与子痫前期(Pre-eclampsia,PE)发生发展的相关性,为临床早期诊断、病情严重程度评估提供新的方向和依据。方法本试验测定了2016年3月至2018年3月65例PE患者和65例血压正常的孕妇血清Gas6的浓度,观察两组血清Gas6浓度的差异,分析Gas6与脂代谢、炎症以及PE病情严重程度的相关性,进一步探讨其在PE中发挥作用的机制以及临床意义。结果PE组血清Gas6水平高于对照组(t=15.081,P<0.05)。SPE组血清Gas6水平高于MPE组(t=11.680,P<0.05)。SBP、DBP、TG、TCH、Upro、ALT、BUN、Cr与PE病情严重程度呈正相关(P<0.01)。Gas6与SBP、DBP、TG、Upro、Cr呈正相关(P<0.001)。结论PE患者血清Gas6呈高表达,与本病的发生发展密切相关,其可能通过影响血脂代谢、血管内皮功能、血压、炎性反应以及肾功能而参与了PE的发生发展过程。

Objective To explore the correlation between the level of Growth Arrest-Specific 6(Gas6)and the occurrence and development of preeclampsia(PE),and to provide a new direction and basis for early clinical diagnosis and evaluation of the severity of the disease.Methods This experiment measured the serum Gas6 concentration of 65 patients with PE and 65 pregnant women with normal blood pressure from March 2016 to March 2018.The changes of serum Gas6 concentration of PE patients were observed,and the relationship between Gas6 and lipid metabolism,inflammation,and PE conditions were investigated.The relevance of severity,further explore the mechanism and clinical significance of its role in PE.Results The level of serum Gas6 in the PE group was higher than that in the control group(t=15.081,P<0.05).The level of serum Gas6 in the SPE group was higher than that in the MPE group(t=11.680,P<0.05).SBP,DBP,TG,TCH,Upro,ALT,BUN,Cr were positively correlated with the severity of PE(P<0.01).Gas6 is positively correlated with SBP,DBP,TG,Upro and Cr(P<0.001).Conclusion The high expression of Gas6 in the serum of PE patients is closely related to the occurrence and development of this disease.It may participate in the occurrence and development of PE by affecting lipid metabolism,vascular endothelial function,blood pressure,inflammation and renal function.