三维适形放疗联合奥沙利铂、卡培他滨改善进展期胃癌手术患者的预后

Effects of three-dimensional conformal radiotherapy combined with oxaliplatin and capecitabine on the prognosis of patients with advanced gastric cancer

目的:探讨三维适形放疗联合奥沙利铂、卡培他滨对进展期胃癌患者术后的辅助治疗效果。方法:92例进展期胃癌腹腔镜D2根治术后患者,随机分为研究组和对照组,每组46例。对照组采用奥沙利铂、卡培他滨化疗,研究组在对照组的基础上采用三维适形放疗。分析两组患者血清肿瘤标志物CEA、CA19-9水平及术后生存情况。结果:治疗后,研究组血清CEA、CA19-9水平低于对照组,差异有统计学意义(P<0.05);术后2年、3年研究组无疾病进展生存率、总生存率均高于对照组(P<0.05)。结论:三维适形放疗联合奥沙利铂、卡培他滨可有效下调肿瘤标志物表达,控制进展期胃癌术后患者的病情,延长生存时间。

Objective:To investigate the adjuvant therapeutic effects of three-dimensional conformal radiotherapy combined with oxaliplatin and capecitabine on the prognosis of patients with advanced gastric cancer.Methods:A total of 92 patients with advanced gastric cancer undergoing laparoscopic D2 radical resection were randomized into study group and control group,each with 46 cases.The control group received oxaliplatin and capecitabine chemotherapy,while the study group received three-dimensional conformal radiotherapy on the basis of the control group.The serum tumor marker CEA and CA19-9 levels,and the postoperative survival were compared between both groups.Results:The serum CEA and CA19-9 levels of the study group after treatment were lower than those of the control group,which were of statistical differences(P<0.05);the disease progression-free survival rate and overall survival rate of the study group were higher than those of the control group at 2 years and 3 years after operation(P<0.05).Conclusion:Three-dimensional conformal radiotherapy combined with oxaliplatin and capecitabine can effectively down-regulate the expressions of tumor markers,control the condition of patients with advanced gastric cancer after surgery,and prolong their survival time.