急性ST段抬高型心肌梗死患者血清miR-1-3p、H-FABP及S100A/B表达与病情、近期预后的相关性分析

Correlations between Expressions of Serum miR-1-3p,H-FABP and S100A/B with Pathogenetic Conditions and Short-Term Prognoses of Patients with Acute ST-segment Elevation Myocardial Infarction

目的探讨急性ST段抬高型心肌梗死(STEMI)患者血清微小核糖核酸(miR)-1-3p、心脏型脂肪酸结合蛋白(H-FABP)及钙卫蛋白(S100A/B)表达与病情、近期预后的相关性。方法选取2017年3月—2020年5月我院收治的104例STEMI患者为观察组,收集98例同期在本院进行体检的无心肌梗死者为对照组。比较2组血清miR-1-3p、H-FABP和S100A/B水平,分析不同miR-1-3p、S100A/B及H-FABP表达与STEMI患者病情进展、近期预后及影响预后死亡的危险因素。结果与对照组比较,观察组miR-1-3p水平显著降低,H-FABP、S100A/B水平显著升高,差异有统计学意义(P<0.01)。miR-1-3p、H-FABP、S100A/B表达水平与STEMI患者年龄、合并糖尿病、脑梗死史、心源性休克、心律失常、心力衰竭有相关性(P<0.05)。随访3个月,STEMI患者病死率为10.58%(11/104),且miR-1-3p低表达、H-FABP及S100A/B高表达者病死率更高(P<0.05)。年龄≥60岁、有脑梗死史、心源性休克、心律失常、心力衰竭、miR-1-3p低表达、H-FABP和S100A/B高表达是影响STEMI近期预后生存的独立危险因素(P<0.05)。结论与无心肌梗死者比较,STEMI患者血清miR-1-3p浓度更低,H-FABP、S100A/B浓度更高;miR-1-3p、H-FABP和S100A/B的表达与该类患者的疾病进展及近期预后密切相关。

Objective To investigate correlations between expressions of serum micro-ribonucleic acid-1-3p(miR-1-3p),heart type fatty acid binding protein(H-FABP)and calprotectin(S100A/B)with pathogenetic conditions and short-term prognoses of patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 104 patients with acute STEMI admitted during March 2017 and May 2020 were selected as observation group,while another 98 healthy people without myocardial infarction who had undergone physical examination at the same period were selected as control group.Serum levels of miR-1-3p,H-FABP,and S100A/B were compared between two groups.Correlations between different expressions of miR-1-3p,S100A/B and H-FABP with disease progress and short-term prognoses of patients with acute STEMI,and risk factors affected prognoses and death were analyzed.Results In observation group,miR-1-3p level was significantly lower,while H-FABP and S100A/B levels were significantly higher than those in control group(P<0.01).The expressions of miR-1-3p,H-FABP and S100A/B were related to age,combined with diabetes,history of cerebral infarction,cardiogenic shock,arrhythmia and heart failure of STEMI patients(P<0.05).Mortality rate of patients with acute STEMI was 10.58%(11/104)with follow-up for 3-months,and the mortality rates of patients with low miR-1-3p expression,high expressions of H-FABP and S100A/B were higher(P<0.05).Age equal or more than 60 years old,having history of cerebral infarction,cardiogenic shock,arrhythmia,heart failure,low expression of miR-1-3p,high expressions of H-FABP and S100A/B were independent risk factors affecting the short-term prognoses and survival of patients with acute STEMI(P<0.05).Conclusion Compared with those in people without myocardial infarction,serum miR-1-3p concentration is lower,while H-FABP and S100A/B concentrations are higher in STEMI patients.Expressions of miR-1-3p,H-FABP and S100A/B are closely related to patient's disease progression and short-term prognoses.