杏芎氯化钠注射液辅助治疗缺血性脑卒中的效果及安全性观察

Clinical Efficacy and Safety of Xingxiong Sodium Chloride Injection in Adjuvant Treatment of Patients with Cerebral Ischemic Stroke

目的探讨杏芎氯化钠注射液辅助治疗缺血性脑卒中的效果及安全性。方法选取2017年10月—2019年10月我院收治的缺血性脑卒中102例,按治疗方法不同分为观察组54例和对照组48例。对照组采用常规治疗,观察组在对照组基础上联合杏芎氯化钠注射液,均治疗2周。比较2组临床疗效,治疗前后脑源性神经营养因子(BDNF)、同型半胱氨酸(HCY)、血浆黏度、全血黏度、纤维蛋白原水平和美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分及治疗期间不良反应。结果观察组总有效率高于对照组(P<0.05)。与治疗前比较,2组治疗后BDNF水平及Barthel指数评分升高,HCY水平及NIHSS评分降低,且观察组变化较对照组更显著,差异有统计学意义(P<0.01)。与治疗前比较,2组治疗后血浆黏度、全血黏度、纤维蛋白原均降低,且观察组低于对照组,差异有统计学意义(P<0.01)。2组治疗期间均未发生不良反应。结论杏芎氯化钠注射液辅助治疗缺血性脑卒中,可显著提高临床疗效,有效纠正血液流变学异常,改善脑部微循环障碍,促进神经功能恢复,提高日常生活活动能力,且安全性好。

Objective To investigate clinical efficacy and safety of Xingxiong Sodium Chloride Injection in adjuvant treatment of patients with cerebral ischemic stroke.Methods A total of 102 patients with cerebral ischemic stroke admitted during October 2017 and October 2019 were selected,and the patients were divided into observation group(n=54)and control group(n=48)according to different treatment methods.Control group was treated with conventional treatment,while observation group was added with Xingxiong Sodium Chloride Injection on the basis of treatment for control group.All the patients were treatment for 2 weeks.Clinical efficacy,levels of brain-derived neurotrophic factor(BDNF),homocysteine(Hcy),plasma viscosity,whole blood viscosity and fibrinogen,the National Institutes of Health Stroke Scale(NIHSS)score and Barthel index score before and after treatment,and incidence rate of adverse reactions during treatment were compared in two groups.Results The total effective rate in observation group was significantly higher than that in control group(P<0.05).After treatment,BDNF levels and Barthel index scores were significantly increased,while Hcy levels and NIHSS scores were significantly decreased compared with those before treatment in two groups,and the changes in observation group were more significant than those in control group(P<0.01).After treatment,levels of plasma viscosity,whole blood viscosity and fibrinogen were significantly decreased compared with those before treatment in two groups,and the levels in observation group were significantly lower than those in control group(P<0.01).No obvious adverse reactions occurred during the treatment in both groups.Conclusion Xingxiong Sodium Chloride Injection in adjuvant treatment of patients with cerebral ischemic stroke may significantly improve clinical efficacy,effectively treat the abnormal hemorheology,improve the cerebral microcirculation disturbance,promote recovery of nerve function and improve the ability of daily living activities with good safety.