PET-CT SUV值对结直肠癌患者术后复发与转移的诊断价值

The Diagnostic Value of PET-CT SUV for Postoperative Recurrence and Metastasis of Colorectal Cancer

目的:探究结直肠癌患者术前正电子发射计算机断层显像(PET-CT)标准摄取值(SUV值)变化,分析PET-CT SUV值对结直肠癌术后复发与转移的诊断预测价值。方法:纳入符合本文入组条件的50例结直肠癌患者为观察对象,对其予以回顾性分析,纳入时间为2017年11月至2020年8月期间,于术前对50例患者行全身PET-CT检查并计算结直肠癌病灶特指区域的最高SUV值(SUVmax),随访观察SUVmax与复发或者转移的相关性,分析SUVmax对结直肠癌复发与转移的诊断效能。结果:随访时间中位数为23.5个月,随访率为100%,50例患者中,24例出现局部复发或者转移,26例患者则无复发与转移。术后出现局部复发或者转移的患者术前SUVmax值为5.3±2.3,术后未发生复发转移的患者术前SUVmax值为2.7±0.6,前者术前SUVmax值明显高于后者,差异有统计学意义(t=4.587,P<0.05)。术前SUVmax=4.2时,对结直肠癌复发与转移的诊断敏感度为72.0%,特异性为100.0%,阴性预测与阳性预测值分别为73.0%与100.0%。结论:结直肠癌患者术前SUVmax值越高,近期出现肿瘤复发与转移的几率就越大,术前的SUV值对于结直肠癌患者复发与转移预测有重要价值。

Objective:To explore the changes in the standard uptake value(SUV)of positron emission computed tomography(PET-CT)in patients with colorectal cancer before surgery,and to analyze the diagnostic predictive value of PET-CT SUV for postoperative recurrence and metastasis of colorectal cancer.Methods:A total of 50 patients with colorectal cancer,from November 2017 to August 2020,who met the inclusion criteria in this study were included as observation subjects for retrospective study.The 50 patients underwent whole-body PET-CT examination before surgery,and the highest SUV(SUVmax)in the specific area of colorectal cancer lesions was calculated.In the follow-up the correlation between SUVmax and recurrence or metastasis was observed,and the diagnostic efficacy of SUVmax for colorectal cancer recurrence and metastasis was analyzed.Results:The median follow-up time was 23.5 months,and the follow-up rate was 100%.Of the 50 patients,24 had local recurrence or metastasis,and 26 patients had no recurrence or metastasis.The preoperative SUVmax of patients with local recurrence or metastasis after operation was(5.3±2.3),and the preoperative SUVmax of patients without recurrence and metastasis after operation was(2.7±0.6).The preoperative SUVmax of the former was significantly higher than the latter,and the difference was statistically significant(t=4.587,P<0.05).When preoperative SUVmax=4.2,the diagnostic sensitivity and specificity of colorectal cancer recurrence and metastasis were 72.0%and 100.0%respectively,and the negative and positive predictive values were 73.0%and 100.0%respectively.Conclusion:The higher the preoperative SUVmax of colorectal cancer patients,the greater the chance of tumor recurrence and metastasis in the near future.The preoperative SUV has important value in predicting the recurrence and metastasis of colorectal cancer patients.