瘢痕子宫患者外周血T淋巴细胞Th1/Th2型细胞因子分泌水平检测及意义

Detection of Th1/Th2 Cytokines Secreted by T Lymphocyte in Peripheral Blood in Patients with Scar Uterus and Its Significance

目的:检测瘢痕子宫患者外周血T淋巴细胞Th1/Th2型细胞因子分泌水平,探讨瘢痕子宫形成的可能免疫学机制。方法:选择108例瘢痕子宫患者作为瘢痕子宫组,126例非瘢痕子宫患者作为对照组,分别测定并比较两组外周血T淋巴细胞分泌Th1/Th2型细胞因子水平。结果:瘢痕子宫患者组外周血中T淋巴细胞分泌IFN-γ和IL-12水平高于对照组,差异具有统计学意义;瘢痕子宫患者组外周血中T淋巴细胞分泌IL-4和IL-10水平同对照组比较,差异不具有统计学意义。结论:瘢痕子宫的形成可能与Th1介导的细胞免疫功能异常增强有关。

Objective:The contents of Th1/Th2 cytokines secreted by T lymphocyte in peripheral blood in patients with scar uterus were detected in order to reveal the possible immune mechanism of uterus scar.Methods:A total of 108 patients with scar uterus were made the study group,and another 126 patients without scar uterus were made the control group.The contents of Th1/Th2 cytokines secreted by T lymphocyte in peripheral blood in both groups were detected.Results:The contents of IFN-γand IL-12 secreted by lymphocytes in peripheral blood in experimental group were higher than those in control group,and the differences were statistically significant.But compared to the control group,the contents of IL-4 and IL-10 secreted by lymphocytes in peripheral blood in the study group were seen to be with no statistical difference.Conclusion:Chances are that the formation of uterus with scar is related to the increase of cellular immunity mediated by Th1 cells.