母婴血型不合对新生儿溶血病的影响

An Analysis of the Effect of Maternal-Infant Blood lGroup Incompatibility on Neonatal Hemolysis

目的:探讨母婴ABO血型不合患者中抗体效价分布情况及对新生儿溶血病的影响。方法:收集760例O型Rh阳性血型(其丈夫为非O型Rh阳性血)的产妇及其分娩的新生儿的临床资料,回顾性分析ABO血型不合孕妇抗体效价分布及对新生儿溶血病的影响。结果:760例ABO血型不合的患者中,随着孕妇年龄、孕产次的增加,效价呈上升趋势,差异有统计学意义。丈夫血型为A/B/AB型的各组间抗体效价的差异无统计学意义。随着孕妇血清IgG抗A(B)抗体效价的升高,新生儿溶血病的发病率也上升。结论:孕期动态监测ABO血型不合的患者抗体效价水平对减少母婴血型不合引起的新生儿溶血病及提高出生人口素质有重要意义。

Objective:To investigate the high distribution of antibody titers in maternal-fetal ABO blood type incompatibility and its effect on the newborn with ABO blood type incompatible hemolytic disease.Methods:A retrospective analysis of 760 type O Rh-negative parturients(whose husbands are not type O Rh-negative)and their newborns is made to discuss the high distribution of antibody titers and the effect on hemolysis of newborns.Results:Among 760 pregnant women with ABO incompatibility,the titer increases with the increasing of gestational time and gestational age,and the difference is statistically significant.These pregnant women are sub-grouped according to their husbands'ABO blood type,and there is no significant difference in antibody titers between groups.With the increasing of antibody titer,the incidence of hemolytic disease in newborns is on the rise.Conclusion:Dynamic monitoring of maternal antibody titers during pregnancy is significant to reducing neonatal hemolytic disease caused by maternal-fetal ABO blood type incompatibility and can improve the quality of the birth population.