健脾理气方对37例儿童多发性抽动症抽动积分及临床疗效观察

Tic Score and Clinical Efficacy Observation of Jianpi Liqi Decoction on 37 Cases of Tourette’s Disease

目的:研究健脾理气方对小儿多发性抽动症(TS)抽动积分的影响,评价其临床疗效。方法:选取2014年1月-2015年12月甘肃省平凉市中医医院儿科收治的74例TS患儿,按入院就诊顺序随机分为观察组和对照组。观察组37例采用健脾理气方治疗,对照组37例给予常规西药硫酸泰必利治疗,疗程为4周,均持续治疗6个疗程,采用耶鲁综合抽动严重程度量表(YGTSS)评估两组抽动积分变化,比较治疗效果。结果:两组治疗前YGTSS抽动积比较,差异无统计学意义(P>0.05),治疗3个月、6个月后均较治疗前明显降低,差异有统计学意义(P<0.05);观察组治疗6个月时YGTSS抽动积分较对照组明显降低,差异,差异有统计学意义(F=34.75,P<0.05);观察组治疗总显效率(83.78%)高于对照组(62.16%),且不良反应率(5.41%)低于对照组(24.32%),差异均有统计学意义(Z疗效=3.019, Z不良反应=4.376,P<0.05)。结论:中药健脾理气方能够显著降低小儿TS抽动积分,减轻和改善抽动症状,且安全性高,临床疗效优于常规西药,具有较好的临床应用价值。

OBJECTIVE To study the effect of Jianpi Liqi recipe on the tic score of children with polytractile tourette syndrome (TS), to evaluate its clinical efficacy. METHODS 74 children with TSwere selected and randomly divided into the observation group and the control group according to the order of admission from Januany,2014 to December,2015. In the observation group,37 cases were treated with Jianpi Liqi recipe;In the control group,37 cases were treated with routine western medicine. 4 week sper course of treatment, continuous treatment for 6 cycles by Yale Global Tic Severity volume table(YGTSS)to evaluate two groups tic integral change compared the therapeutic effect. RESULTS There was no statistical significant difference between the two groups before YGTSS treatment(P>0.05). After 3 months,6 months,the treatment was significantly lower,statistical significant difference(P<0.05). The effective rate(83.78%)in the observation group was higher than that in the control group (62.16%),and the adverse reaction rate(5.41%)was lower than the control group(24.32%),the differences were statistical significant Zclinical efficacy=3.019, Zclinical efficacy=4.376,(P<0.05). CONCLUSION The traditional Chinese medicine Jianpi Liqi could significantly reduce the TS twitch integral in children,and improve tic symptoms and high security. The clinical effect was better than the conventional western medicine,it had good clinical application value.