复方丹参注射液联合拉贝洛尔治疗妊娠高血压综合征临床观察

Clinical Observation of Compound Danshen Injection Combined with Labetalol in the Treatment of Pregnancy-induced Hypertension Syndrome

目的探讨复方丹参注射液联合拉贝洛尔治疗妊娠高血压综合征(妊高征)的效果及对患者微炎症状态、免疫球蛋白的影响。方法选取妊高征患者128例,按随机数字表法分为对照组和观察组,各64例。对照组单纯予以拉贝洛尔治疗,观察组在对照组基础上加用复方丹参注射液治疗,2组均连续治疗10 d。比较2组临床疗效、治疗前后血压、血液流变学指标、血浆因子、肾功能指标、血清炎症因子及免疫球蛋白水平。结果观察组治疗总有效率(95.31%)高于对照组(79.69%),差异有统计学意义(P<0.05)。治疗后10 d,观察组免疫球蛋白IgA、IgG、IgM高于对照组,观察组收缩压(SBP)、舒张压(DBP)、血尿素氮(BUN)、血肌酐(Scr)、β2-微球蛋白(β2-MG)水平低于对照组,差异有统计学意义(P<0.05);观察组纤维蛋白原(Fg)、血浆黏度(plasma viscosity,PV)、红细胞刚性指数(RBC rigidity index,RRI)、全血高切黏度(high blood viscosity,HBV)、全血低切黏度(low blood viscosity,LBV)血液流变学指标以及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)水平低于对照组,差异有统计学意义(P<0.01);观察组超氧化物歧化酶(SOD)、一氧化氮(NO)均高于对照组,而丙二醛(MDA)、内皮素-1(ET-1)低于对照组,差异有统计学意义(P<0.01)。结论复方丹参注射液联合拉贝洛尔治疗妊高征效果显著,能够有效改善肾功能及微炎症状态,提高免疫球蛋白含量,同时还可调节患者血液流变学,改善血管内皮功能,从而起到降压作用。

Objective Study the effect of compound Danshen injection combined with labetalol in the treatment of pregnancy induced hypertension syndrome and its effect on micro-inflammatory status and immunoglobulin.Methods A total of 128 patients with pregnancy-induced hypertension were selected and randomly divided into a control group and an observation group,with 64 cases in each group.The control group was treated with labetalol alone,and the observation group was treated with compound Danshen injection on the basis of the control group.Both groups were treated for 10 consecutive days.The clinical efficacy,blood pressure before and after treatment,blood rheology indexes,plasma factors,renal function indexes,serum inflammatory factors and immunoglobulin levels were compared between the two groups.Results The total effective rate of treatment in the observation group(95.31%)was higher than that in the control group(79.69%),and the difference was statistically significant(P<0.05).Ten days after treatment,the immunoglobulins IgA,IgG,and IgM of the observation group were higher than those of the control group.The observation group had systolic blood pressure(SBP),diastolic blood pressure(DBP),and blood urea nitrogen(BUN),serum creatinine(Scr),andβ2-microglobulin(β2-MG)levels were lower than those of the control group,the difference was statistically significant(P<0.05);the observation group fibrinogen(Fg),plasma viscosity(PV),red blood cell rigidity index(RRI),whole blood high blood viscosity(HBV),whole blood low blood viscosity(LBV),etc.Hemorheology indicators,as well as interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)was lower than that of the control group,and the difference was statistically significant(P<0.01);the observation group had higher levels of superoxide dismutase(SOD)and nitric oxide(NO)in the control group,malonaldehyde(MDA)and endothelin-1(ET-1)were lower than the control group,the difference were statistically significant(P<0.01).Conclusion Compound Danshen injection combined with Labetalol has significant clinical effects on patients with pregnancy-induced hypertension,which can effectively improve the renal function and micro-inflammatory state of patients,increase the content of immunoglobulin,and at the same time regulate the patient’s hemorheology and improve blood vessels endothelial function,which plays a role in lowering blood pressure.