通过mNGS诊断鹦鹉热衣原体肺炎6例救治体会

Diagnosis and treatment experience of 6 cases of chlamydia parrots pneumonia diagnosed by mNGS

社区获得性肺炎是世界范围内发病率和病死率最高的疾病之一,约80%社区获得性肺炎(community-acquired pneumonia, CAP)患者病情较轻,但有20%CAP患者病情严重,尤其是高龄、伴随基础疾病及免疫缺陷患者,可出现严重呼吸衰竭伴多器官功能障碍,其院内死亡率可达25%~50%^([1])。部分CAP患者常规检查难以明确病原菌,经验性抗感染治疗效果差,尤其对于重症CAP患者,及时、准确的明确病原菌很关键。

To investigate the clinical features, diagnosis and treatment of chlamydia parrots pneumonia. The clinical data of 6 cases of Chlamydia psittaci pneumonia in our hospital from August 2019 to December 2020 were retrospectively analyzed, and the clinical characteristics and diagnosis and treatment methods of Chlamydia psittaci pneumonia were summarized.Six cases of chlamydia parrots pneumonia, four cases of severe pneumonia, two cases of mild pneumonia, the main clinical manifestations of were fever and cough. Through the detection of 5 cases of alveolar lavage fluid and 2 cases of blood macro gene second generation sequencing(mngs), Chlamydia psittaci were found. After doxycycline or azithromycin, treatment were improved and discharged.The early manifestations of chlamydia parrots pneumonia are not typical, so it is possible to conduct mNGS detection as soon as possible, and conduct accurate anti-infection treatment, doxycycline has definite efficacy in chlamydia parrots pneumonia.