上尿路尿路上皮癌临床治疗进展

Progress in clinical treatment of upper urinary tract urothelial carcinoma

上尿路尿路上皮癌(UTUC)指发生于肾盂及输尿管的尿路上皮恶性肿瘤。虽然发病率较低,但起病隐匿,侵袭性强且复发率高,随着对该疾病认识的不断深入,对临床诊疗中术前评估、手术及围手术期治疗和预防膀胱复发等方面提出新的思考和挑战。本文就UTUC患者肿瘤风险评估、手术技术以及新辅助和辅助治疗中腔内和全身治疗的最新临床进展作一综述。

Upper urinary tract urothelial carcinoma(UTUC)refers to malignant tumors of the urinary tract that occur in the renal pelvis and ureter.Although the incidence is low,the onset is insidious,invasive,and the recurrence rate is high.With the deepening understanding of the disease,new thinking and challenges have been raised in the aspects of preoperative evaluation,surgery and perioperative treatment and prevention of bladder recurrence.This article reviews the latest clinical advances in cancer risk assessment,surgical techniques,and neoadjuvant and adjuvant therapy for UTUC patients.