盐酸地尔硫[艹卓]片对房颤性心肌病患者心功能及预后的影响

Effect of Diltiazem Hydrochloride on Cardiac Function and Prognosis in Patients with Atrial Fibrillary Cardiomyopathy

目的观察盐酸地尔硫[艹卓]片对房颤性心肌病患者心功能及预后的影响。方法选取2018年8月至2020年6月郑州大学第一附属医院收治的186例房颤性心肌病患者作为研究对象,按照随机数字表法分为对照组和实验组,各93例。对照组接受常规对症治疗(利尿剂、地高辛、β受体阻滞剂、培哚普利),实验组在对照组基础上接受盐酸地尔硫[艹卓]片治疗。比较两组治疗后靶心率(THR)达标率、左心室射血分数(LVEF)、脑钠肽前体(proBNP)、治疗期间活动耐量下降情况、30 d内再入院情况。结果治疗后,实验组患者靶心率达标率高于对照组,差异有统计学意义(P<0.05)。实验组30 d内再入院率低于对照组,差异有统计学意义(P<0.05)。实验组与对照组治疗期间活动耐量下降率差异无统计学意义(P>0.05)。治疗前,两组proBNP、LVEF比较,差异无统计学意义(P>0.05);治疗后,两组proBNP均降低,且实验组低于对照组,差异有统计学意义(P<0.05);两组LVEF均增加,且实验组大于对照组,差异有统计学意义(P<0.05)。结论盐酸地尔硫[艹卓]片能够有效改善房颤性心肌病患者的心功能及预后。

Objective To observe the effect of diltiazem hydrochloride on the cardiac function and Prognosis of Patients with atrial fibrillation cardiomyopathy.Methods A selection of 186 patients with atrial fibrillation cardiomyopathy who were admitted to the First Affiliated Hospital of Zhengzhou University from August 2018 to June 2020 were randomly divided into two groups:an experimental group of 93 cases and a control group of 93 cases.Control group treated with standardized treatment(diuretics,digoxin,βblockers,perindopril),the experimental group treated with standardized treatment and standardized treatment.Comparing the target heart rate(THR)achievement rate,left ventricular ejection fraction(LVEF),brain sodium peptide precursor(proBNP),decreased activity tolerance during treatment,and readmission within 30 days.Results After treatment,the THR achievement rate was higher than that of the control group,and the difference was statistically significant(P<0.05).The rate of readmission in the experimental group within 30 days was lower than the control group and the difference was statistically significant(P<0.05).There was no statistical difference in decreased activity resistance between experiment and control groups(P>0.05).Before treatment,the differences between the two groups of proBNP and LVEF were not satistically significant(P>0.05);after treatment,the proBNP was reduced in both groups,and the experimental group was lower than the control group,the difference was statistically significant(P<0.05),the two groups of LVEF increased,and the experimental group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion Diltiazem hydrochloride tablets can effectively improve cardiac function and prognosis in patients with atrial fibrillation cardiomyopathy.