基于免疫型肠内营养的康复护理在颅脑损伤术后患者中的应用效果

Effect of Rehabilitation Nursing Based on Immune Enteral Nutrition on Nerve Function of Patients Undergoing Craniocerebral Injury

目的探讨基于免疫型肠内营养的康复护理在颅脑损伤术后患者中的应用效果。方法选取2017年8月至2019年6月于郑州市第一人民医院接受手术治疗的94例颅脑损伤患者作为研究对象,按照随机数字表法分为观察组和对照组,各47例。对照组接受常规康复护理,观察组在对照组的基础上接受基于免疫型肠内营养的康复护理。通过美国国立卫生研究院卒中量表(NIHSS)评估两组患者护理前、护理2个月后的神经功能。评估护理前、护理2个月后两组患者的炎症因子水平[C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]和肠黏膜屏障功能[二胺氧化酶(DAO)、肠型脂肪酸结合蛋白(IFABP)、D-乳酸]。结果护理前,两组NIHSS评分比较,差异无统计学意义(P>0.05);护理2个月后,两组NIHSS评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。护理前,两组血清CRP、PCT、TNF-α、IL-6水平比较,差异无统计学意义(P>0.05);护理2个月后,两组血清CRP、PCT、TNF-α、IL-6水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。护理前,两组DAO、IFABP、D-乳酸水平比较,差异无统计学意义(P>0.05)。护理2个月后,两组DAO、IFABP、D-乳酸水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论基于免疫型肠内营养的康复护理应用于颅脑损伤手术患者中效果确切,可改善患者神经功能,抑制炎症反应,改善肠黏膜屏障功能。

Objective To explore the application effect of rehabilitation nursing based on immune enteral nutrition in patients with craniocerebral injury.Methods A total of 94 cases of craniocerebral injury patients who received surgical treatment in Zhengzhou First People’s Hospital from August 2017 to June 2019 were selected as the research objects,and they were randomly divided into observation group and control group,47 cases in each group.The control group received routine rehabilitation nursing,and the observation group received rehabilitation nursing based on immune enteral nutrition on the basis of the control group.National Institutes of Health stroke scale(NIHSS)was used to evaluate the neurological function of the two groups before and after 2 months of nursing.The levels of inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]were evaluated before and after 2 months of nursing.The intestinal mucosal barrier function[diamine oxidase(DAO),intestinal fatty acid binding protein(IFABP),D-lactic acid]was evaluated before and after 2 months nursing.Results Before nursing,there was no statistical significance in NIHSS score between the two groups(P>0.05).After 2 months of nursing,NIHSS scores of the two groups were decreased;the observation group was lower than the control group,and the differences were statistically significant(P<0.05).Before nursing,there was no significant difference in serum CRP,PCT,TNF-αand IL-6 levels between the two groups(P>0.05).After 2 months of nursing,the levels of CRP,PCT,TNF-αand IL-6 in the two groups were decreased;the observation group was lower than the control group,and the differences were statistically significant(P<0.05).Before nursing,there was no significant difference in serum DAO、IFABP、D-lactic acid levels between the two groups(P>0.05).After 2 months of nursing,the levels of DAO、IFABP、D-lactic acid in the two groups were decreased;the observation group was lower than the control group,and the differences were statistically significant(P<0.05).Conclusion The effect of immune enteral nutrition based rehabilitation nursing in patients with craniocerebral injury surgery is exact.It can improve neurological function,inhibit inflammatory reaction and improve intestinal mucosal barrier function.