网状蛋白1C与非小细胞肺癌预后的关系

The relationship between reticulin 1C and the prognosis of non-small cell lung cancer

目的分析网状蛋白1C(RTN-1C)与非小细胞肺癌(NSCLC)预后的关系。方法选择2016年1月至2017年10月间就诊的116例NSCLC患者作为研究对象,均接受根治性手术切除治疗。用蛋白质免疫印迹法检测NSCLC患者癌组织和根治性切除术前、术后的外周血单个核细胞中RTN-1C水平,分析其与预后的关系。结果随访3年,116例NSCLC患者中50例存活(生存组),66例死亡(死亡组)。生存组的术前RTN-1C、术后RTN-1C水平均低于死亡组,ΔRTN-1C(术前RTN-1C和术后RTN-1C的差值)水平高于死亡组,差异均有统计学意义(P<0.05)。术后RTN-1C评价NSCLC预后的ROC曲线下面积大于术前RTN-1C和ΔRTN-1C,差异均有统计学意义(P<0.05)。高RTN-1C组的中位生存时间低于低RTN-1C组,差异有统计学意义(P<0.05)。COX回归分析结果显示分化程度高是NSCLC预后的独立保护因素(P<0.05),TNM分期Ⅲ期和术后RTN-1C>0.49是NSCLC预后的独立危险因素(P<0.05)。结论NSCLC患者根治性切除手术后外周血单个核细胞中RTN-1C水平高提示预后不良风险高。

Objective To analyze the relationship between reticulin 1C(RTN-1C)and the prognosis of non-small cell lung cancer(NSCLC).Methods 116 patients with NSCLC who were treated from January 2017 to October 2018 were selected as the research objects,all patients received radical resection.Western blotting was used to detect RTN-1C levels in cancer tissues and peripheral blood mononuclear cells before and after radical resection of patients with NSCLC,and its relationship with prognosis was analyzed.Results After 3 years of follow-up,50 of 116 NSCLC patients survived(survival group)and 66 died(death group).The levels of preoperative RTN-1C and postoperative RTN-1C of the survival group were lower than those of the death group,and the level of RTN-1C(the difference between preoperative RTN-1C and postoperative RTN-1C)was higher than that of the death group,the differences were statistically significant(P<0.05).The area under the ROC curve of postoperative RTN-1C to evaluate the prognosis of NSCLC was larger than that of preoperative RTN-1C and RTN-1C,and the differences were statistically significant(P<0.05).The median survival time of the high RTN-1C group was lower than that of the low RTN-1C group,and the difference was statistically significant(P<0.05).COX regression analysis showed that high differentiation was an independent protective factor for the prognosis of NSCLC(P<0.05),TNM stage III and postoperative RTN-1C>0.49 were independent risk factors for the prognosis of NSCLC(P<0.05).Conclusion A high level of RTN-1C in peripheral blood mononuclear cells after radical resection of NSCLC patients shows a high risk of poor prognosis.