白介素-31基因多态性与隐睾发病易感性的相关性

Association of interleukin-31 gene polymorphisms with risk of cryptorchidism in a Chinese population

目的探讨白细胞介素-31(IL-31)基因多态性与隐睾发病易感性之间的关系。方法IL-31基因的两个单核苷酸多态位点,rs7977932(C/G),rs4758680(C/A)被纳入此研究进行探究。本研究采用聚合酶链式反应-限制性片段长度多态性方法对IL-31基因的单核苷酸多态性进行鉴定,共对112例隐睾患者和425例健康对照者进行了一项病例对照研究。结果隐睾症患者rs4758680的C等位基因频率明显高于对照组(89%vs83%,P=0.02,OR=0.58,95%CI=0.37~0.92)。与显性模型中CC基因型相比,隐睾患者携带CA/AA基因型的频率显著降低(P=0.03,OR=0.58,95%CI=0.35~0.96)。结论IL-31基因多态性与中国人群隐睾的遗传易感性有关。与CC基因型相比,rs4758680的A等位基因携带者(CA/AA基因型)是隐睾遗传易感性的保护因素。

Objective This study aims to investigate the possible association between Interleukin-31(IL-31)gene polymorphisms and cryptorchidism risk.Methods Two single nucleotide polymorphisms of IL-31,rs7977932(C/G)and rs4758680(C/A),were selected to be investigated in this study.Polymerase chain reaction-restriction fragment length polymorphism methods were used to discriminate the selected single nucleotide polymorphisms of IL-31 gene.A case-control study of 112 cryptorchidism patients and 425 healthy controls was conducted.Results The frequencies of the C allele of rs4758680 in the patients with cryptorchidism were significantly higher compared with those in controls(89%vs83%,P=0.02,OR=0.58,95%CI=0.37-0.92).Compared with CC genotype in dominant model,notable decreased frequencies of A carriers(CA/AA genotypes)were observed in cryptorchidism patients(P=0.03,OR=0.58,95%CI=0.35-0.96).Conclusion The results demonstrated that IL-31 gene polymorphisms were associated with the genetic susceptibility to cryptorchidism in a Chinese population.Compared with CC genotype,the A carriers(CA/AA genotypes)of rs4758680 were protect factors in cryptorchidism susceptibility.