分析参芪地黄降糖颗粒治疗妊娠期糖尿病(GDM)的临床疗效

Analysis of the Clinical Efficacy of Shenqi Dihuang Jiangtang Granules in the Treatment of Gestational Diabetes Mellitus(GDM)

目的探讨对妊娠期糖尿病(GDM)患者采用参芪地黄降糖颗粒药物进行治疗后获得临床效果。方法将该院2017年6月-2020年4月收治的70例GDM患者通过数字奇偶法分组;治疗组(35例):采用常规治疗+参芪地黄降糖颗粒完成GDM疾病治疗;参照组(35例):采用常规治疗方式完成GDM治疗;就组间治疗总有效率、治疗不良反应(肝功能异常、胃肠道不适、低血糖)发生率、不同时间段血糖水平(空腹血糖水平、餐后2 h血糖水平)展开对比。结果治疗组GDM患者治疗总有效率(94.29%)高于参照组(68.57%)明显,差异有统计学意义(P<0.05);两组不良反应集中于肝功能异常、胃肠道不适、低血糖方面,治疗组GDM患者总不良反应发生率(8.57%)同参照组(17.14%)比较,差异无统计学意义(P>0.05);治疗前,治疗组GDM患者FPG(7.96±1.66)mmol/L、2 hPG(12.57±2.45)mmol/L同参照组FPG(7.89±1.62)mmol/L、2 hPG(12.52±2.49)mmol/L比较差异无统计学意义(P>0.05);治疗后,治疗组GDM患者FPG(5.25±1.16)mmol/L、2 hPG(10.22±1.95)mmol/L均低于参照组FPG(6.05±1.16)mmol/L、2 hPG(11.25±1.90)mmol/L明显,差异有统计学意义(P<0.05)。结论参芪地黄降糖颗粒有效运用,可将GDM治疗效果显著提升,不会导致GDM患者肝功能异常、胃肠道不适、低血糖等系列不良反应增加,并且能够将空腹血糖水平、餐后2 h血糖水平显著降低,最终实现GDM患者病情改善、预后提升。

Objective To explore the clinical effects of Shenqi Dihuang Jiangtang granules in patients with gestational diabetes(GDM).Methods 70 cases of GDM patients admitted to the hospital from June 2017 to April 2020 were grouped by digital parity method;treatment group(35 cases):conventional treatment+Shenqi Dihuang Jiangtang granules were used to complete the treatment of GDM disease;reference group(35 cases):GDM treatment was completed by conventional treatment methods;the total effective rate of treatment between groups,the incidence of treatment adverse reactions(abnormal liver function,gastrointestinal discomfort,hypoglycemia),blood glucose levels in different time periods(fasting blood glucose levels,2h blood glucose level after a meal)were compared.Results The total effective rate of treatment for GDM patients in the treatment group(94.29%)was significantly higher than that of the reference group(68.57%),the difference was statistically significant(P<0.05);the adverse reactions of the two groups were concentrated in liver function abnormalities,gastrointestinal discomfort,and hypoglycemia;the treatment group of the total adverse reaction rate(8.57%)of GDM patients was not significantly different from that of the reference group(17.14%),the difference was not statistically significant(P>0.05);before treatment,FPG(7.96±1.66)mmol/L,2 hPG(12.57±2.45)mmol/L of GDM patients in the treatment group,compared with the reference group of FPG(7.89±1.62)mmol/L and 2 hPG(12.52±2.49)mmol/L were not significantly different(P>0.05);after treatment,the treatment group had FPG(5.25±1.16)mmol/L and 2 hPG(10.22±1.95)mmol/L were significantly lower than the reference group FPG(6.05±1.16)mmol/L and 2 hPG(11.25±1.90)mmol/L,the difference was statistically significant(P<0.05).Conclusion The effective use of Shenqi Dihuang Jiangtang Granules can significantly improve the therapeutic effect of GDM,and will not cause abnormal liver function,gastrointestinal discomfort,hypoglycemia and other adverse reactions in patients with GDM.It can also reduce fasting blood glucose levels and 2h after meals.The blood glucose level is significantly reduced,and ultimately the condition of GDM patients is improved and the prognosis is improved.