不同性别患者晚发强直性脊柱炎临床特征比较

Comparison of the clinical pictures of late-onset ankylosing spondylitis between males and females

目的:比较不同性别患者晚发强直性脊柱炎的临床特征。方法:收集2010~2019年在弋矶山医院风湿科住院的晚发强直性脊柱炎患者资料,分成男性组和女性组,比较两组临床资料并做统计学分析。结果:男性组起病时炎性腰背痛更常见,差异有统计学意义(P<0.05);男性骶髂关节炎和骨桥虽然比女性严重,但差异无统计学意义(P>0.05);两组发病年龄,确诊时间,外周关节受累部位,关节外表现(葡萄膜炎、血尿),HLA-B27阳性率,炎症指标血沉及C反应蛋白差异均无统计学意义(P>0.05)。结论:男性晚发强直性脊柱炎起病时腰背痛多于女性,但两组其他特征并无明显区别。

Objective:To compare the clinical features of patients with late-onset ankylosing spondylitis(LOAS)in defferent genders.Methods:Case data were collected from patients with LOAS treated in our department between 2010 and 2019,and divided into male group and female group.Then the clinical pictures were compared between groups and statistically analyzed.Results:Back pain at onset was more common in males.The difference was significant between the two groups.Males had more serious sacroiliitis and bone-bridge formation than females,yet the difference was insignificant.There was also no significant difference in onset age,the time of diagnosis,peripheral joint involvement,extra-articular manifestations(including uveitis,hematuria),HLA-B27 expression,and levels of erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)indicative of inflammation between groups.Conclusion:Back pain at onset of LOAS is more common in males than in females,yet there is no significant difference concerning other clinical pictures between genders.