低剂量替罗非班治疗急性缺血性脑卒中的疗效观察

Efficacy of low-dose tirofiban in acute ischemic stroke

目的观察低剂量替罗非班治疗急性缺血性脑卒中的疗效。方法140例急性缺血性脑卒中患者随机分为治疗组和对照组,分别给予低剂量替罗非班+阿司匹林+氢氯吡格雷或阿司匹林治疗,比较两组疗效及NIHSS、改良Rankin评分。结果治疗组疗效明显优于对照组(P<0.01),而NIHSS、改良Rankin评分低于对照组(P<0.01或0.05)。两组出血风险差异无统计学意义(P>0.05)。结论低剂量替罗非班可有效、安全地治疗急性缺血性脑卒中。

Objective To observe the efficacy of low-dose tirofiban in acute ischemic stroke(AIS).Methods A total of 140 AIS patients were randomly divided into treatment and control groups,each receiving low-dose tirofiban+aspirin+clopidogrel or single aspirin therapy.Clinical efficacy,NIHSS and modified Rankin scores were compared between 2 groups.Results Compared with control group,clinical efficacy was better(P<0.01),while NIHSS modified Rankin scores were lower(P<0.01 or 0.05)in treatment group.Hemorrhage risk was comparable between 2 groups(P>0.05).Conclusion Low-dose tirofiban is effective and safe in the treatment of AIS.