100例肺曲菌球感染患者临床特征分析

Clinical characteristics of 100 patients with pulmonary aspergilloma infection

目的分析100例肺曲菌球感染患者的临床特征,探讨导致肺曲菌球感染的危险因素。方法回顾性分析2014年3月至2015年12月本院收治的100例肺曲菌球感染患者(观察组)(男82例,女18例)及50例支气管扩张合并咯血患者(对照组)(男38例,女12例)的临床资料,分析肺曲菌球感染的临床特征及导致肺曲菌球感染的危险因素。结果两组均以男性、咳嗽、咳痰、咯血、肺内湿啰音及肺CT见渗出影发生率均较高,但两组间比较,差异均无统计学意义(均P>0.05);而观察组长期使用抗生素,合并陈旧性肺结核、慢性阻塞性肺疾病(COPD)、恶性肿瘤,肺内晕轮征、空气新月征、空洞及上肺病变的发生率为71.00%(71/100)、81.00%(81/100)、63.00%(63/100)、29.00%(29/100)、88.00%(88/100)、68.00%(68/100)、81.00%(81/100),明显高于对照组[48.00%(24/50)、24.00%(12/50)、20.00%(10/50)、6.00%(3/50)、6.00%(3/50)、20.00%(10/50)、0.00%(0/50)](均P<0.05)。长期使用抗生素,合并陈旧性肺结核、COPD,肺内晕轮征、空气新月征、空洞及上肺病变为导致肺曲菌球感染的危险因素(均OR>1,P<0.05)。结论肺曲菌球感染具有一定的临床特点,且多种因素均为导致本病发生的危险因素,临床需注意对存在本病危险因素患者的临床诊疗。

Objective To analyze the clinical characteristics of 100 patients with pulmonary aspergilloma infection and explore the risk factors of pulmonary aspergilloma infection.Methods The clinical data of 100 patients with pulmonary aspergilloma infection(observation group)(82 males and 18 females)and 50 patients with bronchiectasis and hemoptysis(control group)(38 males and 12 females)in our hospital from March 2014 to December 2015 were retrospectively analyzed.The clinical features of pulmonary aspergilloma infection and the risk factors of pulmonary aspergilloma infection were analyzed.Results The rates of male,cough,expectoration,hemoptysis,moist rales in lung,and exudative shadow on CT were high in both groups,but there were no statistically significant differences between the two groups(all P>0.05).The rates of long-term use of antibiotics,old tuberculosis,chronic obstructive pulmonary disease(COPD),malignant tumors,halo sign,air crescent sign,cavity,and upper lung lesions in the observation group were 71.00%(71/100),81.00%(81/100),63.00%(63/100),29.00%(29/100),88.00%(88/100),68.00%(68/100),and 81.00%(81/100),which were significantly higher than those in the control group[48.00%(24/50),24.00%(12/50),20.00%(10/50),6.00%(3/50),6.00%(3/50),20.00%(10/50),and 0.00%(0/50)](all P<0.05).Long term use of antibiotics,combined with old tuberculosis,COPD,halo sign,air crescent sign,cavity,and upper lung lesions were the risk factors of pulmonary aspergilloma infection(all OR>1,P<0.05).Conclusion Pulmonary aspergilloma infection has certain clinical characteristics,a variety of factors are the risk factors leading to the occurrence of the disease,and clinical attention should be paid to the clinical diagnosis and treatment of patients with risk factors of the disease.