血清游离胆红素测定的研究进展

Research progress on the determination of serum unbound bilirubin

高胆红素血症是导致新生儿期住院最为常见的疾病。高水平血清游离胆红素有着明显的神经毒性,最终可导致新生儿胆红素脑病。近年来,随着人们对游离胆红素研究的不断深入,检测游离胆红素的方法亦进一步丰富。本文拟在简述胆红素生理及毒性机制、早产儿胆红素脑损伤表现的基础上,对现有检测血清游离胆红素的方法进行综述。

Hyperbilirubinemia is the most common disease leading to hospitalization during the neonatal period.High serum unbound bilirubin level has obvious neurotoxicity,which can eventually lead to neonatal bilirubin encephalopathy.In recent years,with the continuous deepening of research on unbound bilirubin,the methods for detecting unbound bilirubin have been further enriched.This article intends to review the existing methods of detecting serum unbound bilirubin based on a brief description of the physiology and toxicity mechanism of bilirubin,and the manifestations of bilirubin brain damage in premature infants.