抗环瓜氨酸肽抗体对类风湿关节炎的诊断价值

Diagnostic value of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis

目的分析抗环瓜氨酸肽抗体(抗CCP抗体)对类风湿关节炎(RA)的诊断价值。方法选取2019年6月至2020年6月本院收治的60例RA患者作为试验组,选取同期本院收治的60例其他类型风湿病患者作为参照组,另选取同期本院60名健康体检者作为健康组。所有受检者均行抗CCP抗体和类风湿因子(RF)检测。比较三组受检者的抗CCP抗体及RF水平、抗CCP抗体及RF阳性率。将试验组患者根据病程长短分为非早期组和早期组,根据疾病分期分为非骨侵蚀组和骨侵蚀组,分析不同亚组的抗CCP抗体水平。并分析骨侵蚀组不同分期患者的抗CCP抗体水平。结果试验组的抗CCP抗体及RF水平、抗CCP抗体及RF阳性率均明显高于参照组与健康组,差异具有统计学意义(P<0.05)。非早期组的抗CCP抗体水平高于早期组(P<0.05)。非骨侵蚀组的抗CCP抗体水平低于骨侵蚀组(P<0.05)。骨侵蚀组Ⅳ期患者的抗CCP抗体水平明显高于Ⅱ、Ⅲ期(P<0.05)。结论抗CCP抗体可作为RA早期诊断的一个重要指标,诊断价值较高。

Objective To analyze the diagnostic value of anti-cyclic citrullinated peptide antibody(anti-CCP antibody)in rheumatoid arthritis(RA).Methods A total of 60 patients with RA admitted in our hospital from June 2019 to June 2020 were selected as experimental group,60 patients with other types of rheumatism admitted in our hospital at the same period were selected as reference group,and 60 healthy people in our hospital at the same period were selected as healthy group.All subjects were tested for anti-CCP antibody and rheumatoid factor(RF).The levels of anti-CCP antibody and RF,the positive rate of anti-CCP antibody and RF were compared among the three groups.The patients in the experimental group were divided into non-early group and early group according to the course of disease,and were divided into non-bone erosion group and bone erosion group according to the disease stage,the level of anti-CCP antibody in different subgroups were analyzed.The levels of anti-CCP antibody in patients with different stages of the bone erosion group were analyzed.Results The levels of anti-CCP antibody and RF,the positive rate of anti-CCP antibody and RF in the experimental group were significantly higher than those in the reference group and the healthy group,and the difference was statistically significant(P<0.05).The level of anti-CCP antibody in the non-early group was higher than that in the early group(P<0.05).The level of anti-CCP antibody in the non-bone erosion group was lower than that in the bone erosion group(P<0.05).The level of anti-CCP antibody in stageⅣof the bone erosion group was significantly higher than that in stageⅡandⅢ(P<0.05).Conclusion Anti-CCP antibody can be used as an important index in the early diagnosis of RA,the diagnostic value is higher.