生长分化因子11在心血管疾病中的作用

Advances in the role of growth differentiation factor 11 in cardiovascular diseases

生长分化因子11(growth differentiation factor 11,GDF11)是转化生长因子β(transforming growth factor-β,TGF-β)超家族的成员之一,是一种广泛存在于人体中的分泌性蛋白,参与早期胚胎发育,与神经调控、骨骼发育、视网膜和肾脏等组织器官的成熟有关。近年来研究表明,GDF11与衰老、心血管疾病有密切联系,但其具体影响和作用机制一直以来存在争议。部分研究认为,GDF11水平升高可以减轻心肌肥大和炎症损伤,改善血管内皮功能,对动脉粥样硬化、心肌缺血再灌注损伤、增龄相关的心血管功能障碍等有积极效果;但是,该结论目前仍存在争议。该文综述了GDF11在心血管疾病领域的研究进展及主要分歧,以期对相关研究的开展提供参考。

Growth differentiation factor 11(GDF11)is an important member of transforming growth factor-β(TGF-β)superfamily.As a secreted protein widely distributed in human body,it is associated with many physiological activities,including early embryonic and bone development,neural regulation,and maturation of tissues and organs such as retina and kidney.Recent studies have shown that GDF11 is closely related to aging and cardiovascular diseases,but its specific effects and mechanism are controversial.Some studies have drawn the conclusions that increased levels of GDF11 can reduce myocardial hypertrophy,alleviate inflammatory damage and protect the function of vascular endothelial cells.Meanwhile,some studies have reached the opposite conclusions.So the issue that whether GDF11 has a protective effect on cardiovascular diseases remains uncertain.This article reviews the research progress and essential divergence of GDF11 in the field of cardiovascular diseases,in order to provide reference for future investigation.