成人乙型流感口服布洛芬并发横纹肌溶解综合征1例报告并文献回顾

A report on an adult patient with influenza B complicated with rhabdomyolysis syndrome following oral administration of Ibuprofen and related literature review

乙型流行性感冒(乙型流感)并发横纹肌溶解综合征(RM)的病例较为罕见,且大多数为儿童.天津市第一中心医院2019年5月20日收治1例成人乙型流感口服布洛芬后并发RM患者,患者以全身肌肉疼痛、乏力、纳差为主要表现,肌酸激酶(CK)、肌红蛋白(MYO)等心肌酶学指标显著升高,并随着时间延长动态改变.患者入院后立即给予了抗病毒、保肝、碱化尿液、大量补液及营养支持治疗,体温降至正常,乏力及肌肉疼痛症状有所好转;入院2 d患者CK、MYO等血清酶学指标逐渐下降,复查尿常规正常;入院9 d患者症状及各项实验室指标明显好转出院.1个月后门诊复查,患者各项生化指标完全恢复正常.

The patients with influenza B complicated with rhabdomyolysis syndrome(RM)are rare,and most of them are children.Tianjin First Central Hospital admitted an adult influenza B patient complicated with RM after oral administration of Ibuprofen.The main manifestations of the patient were general muscle pain,fatigue and anorexia.Myocardial enzyme indexes,such as creatine kinase(CK),myoglobin(MYO)increased significantly and changed dynamically with extension of time.After admission,he was given antiviral treatment,liver protection,alkalization of urine,infusion of large amount of fluids and nutritional support.Then the patient's body temperature was dropped to normal,and his fatigue and muscle pain symptoms were improved.After admission for 2 days,CK,MYO and other serum enzyme indexes were gradually decreased,and the reexamination of urine routine was normal;after admission for 9 days,the symptoms and various laboratory indicators were obviously improved and the patient was discharged.After 1 month,when the patient was reexamined in the out-patient department,his results of all the above biochemical indicators were completely returned to normal.