对大理白族地区大肠癌合并血吸虫感染患者采用贝伐珠单抗联合化疗治疗的临床效果评价

Evaluation to clinical effects of bevacizumab combined with chemotherapy on the colon cancer accompanied by infection of schistosoma in bai-inhabited Dali region

目的分析对大理白族地区大肠癌合并血吸虫感染患者实施贝伐珠单抗联合化疗治疗的有效性。方法随机将2018年9月-2020年6月在我院收治的的73例大理白族地区大肠癌合并血吸虫感染患者分成2组,针对参照组36例患者实施单纯化疗治疗,针对治疗组37例患者实施贝伐珠单抗联合化疗治疗,对比2组大肠癌患者的治疗效果。结果2组治疗后的生存时间、治疗有效性存在显著差异(P<0.05),有统计学意义;但2组治疗后对比的不良反应发生率无差异(P>0.05),无统计学意义;治疗组治疗前后患者的生活质量明显改善,生理领域、心理领域、社会关系领域得分均较前升高,(P<0.05),但环境领域差异无显著性(P>0.05)。结论针对大理白族地区大肠癌合并血吸虫感染患者实施贝伐珠单抗联合化疗治疗的有效性较为显著,安全性较高,能延长患者的生存时间,治疗后患者的生活质量较治疗前明显改善,达到预期的近期疗效。

Objective To analyze the effectiveness of bevacizumab combined with chemotherapy on patients with both colorectal cancer and schistosomiasis infection in the Bai nationality area of Dali.Methods A total of 73 patients with colorectal cancer and schistosomiasis infection from the Bai ethnic group in Dali admitted to our hospital during September 2018 to June 2020.They were randomly divided into two groups.36 patients in the control group were treated with chemotherapy alone while 37 patients in the treatment group were administered with bevacizumab combined with chemotherapy.The therapeutic efficacy of the two groups was compared.Results The significant differences have been shown in survival time and treatment effectiveness by comparing the two groups(P<0.05),which were statistically significant.However,there was no difference in the incidence of adverse reactions after treatment between the two groups(P>0.05).In the treatment group,the quality of life of the patients after treatment was significantly improved,which inclued the scores in physiological and psychological fields as well as social relations were higher than those before the treatment(P<0.05).Nevertheless,there was no significant difference in environmental fields by comparing the two groups(P>0.05).Conclusions The efficacy and safety of bevacizumab combined with chemotherapy in colorectal cancer patients infected with schistosomiasis in Dali Bai area were remarkable.The quality of life of patients after treatment was significantly improved by comparing to that before treatment,which could prolong the survival time of patients and achieve the expected short-term efficacy.