微生物-肠-脑轴对肥胖调控的研究进展

Advances in Understanding the Regulation of Obesity by Microbiome-Gut-Brain Axis

肥胖已经成为一种全球性的流行病,严重威害人们的健康和生命,预防和治疗肥胖是世界各国面临的重大公共卫生挑战。越来越多的研究发现肥胖的发生和发展与肠道菌群有着密切的关系,肠道菌群与肥胖之间的调控机制成为研究的热点。微生物-肠-脑轴是肠道菌群参与的肠道和大脑的双向信息交流系统,是大脑和肠道功能相互整合、相互调节的途径。近年国内外的研究表明,微生物-肠-脑轴在肥胖调控方面具有重要的贡献,很多物质通过该途径发挥降脂减肥功能。本文综述了肥胖的严峻现状、微生物-肠-脑轴的组成以及调控肥胖的机制,以期为治疗肥胖等代谢疾病提供思路,也为一些降脂物质的机理研究提供了方向。

Obesity has become a global epidemic,posing a serious threat to the lives and health of people.The prevention and treatment of obesity have become a major public health challenge all over the world.More and more studies have shown that the gut microbiota is closely related to the occurrence and development of obesity.The regulatory mechanism of the gut microbiota on obesity has become a research hotspot.The microbiome-gut-brain axis is a bidirectional communication system between the intestine and the brain,which provides a path for the mutual integration and regulation between the brain and gut functions.Recent worldwide studies have shown that the microbiome-gut-brain axis plays an important role in the regulation of obesity,and many substances lower lipids and reduce body mass through this axis.This article reviews the current grim situation of obesity,the composition of microbiome-gut-brain axis and the underlying mechanism of obesity regulation,with the aim of providing ideas for the treatment of metabolic diseases such as obesity and providing directions for exploring the lipid-lowering mechanism of some substances.