打鼾与BMI对高血压患病的交互作用

A study on the interaction of snoring and body mass index on hypertension

目的分析打鼾与BMI对高血压患病的交互作用,以制定合适的预防策略。方法基于2015年9月―2018年6月江苏省心血管病高危人群早期筛查与综合干预项目(China patientcentered evaluative assessment of cardiac events-million persons project,China PEACE-MPP)中82751名≥35岁居民初筛数据,通过Logistic回归分析模型分析打鼾与BMI对高血压患病的影响,并进一步分析其交互作用。结果82751名调查对象中,打鼾者45013人,占比54.40%,BMI≥24 kg/m^(2)者52641人,占比63.61%,高血压患者47295人占比,57.15%。打鼾(OR=1.686,95%CI:1.635~1.738)和BMI≥24 kg/m^(2)(OR=2.242,95%CI:2.172~2.313)人群罹患高血压的风险较高。打鼾与BMI≥24 kg/m^(2)对高血压患病存在相加交互作用(RERI=1.160,AP=0.311,S=1.738),两者同时存在时患高血压风险是两者均不存在时的3.732倍(95%CI:3.582~3.888)。结论打鼾与BMI≥24 kg/m^(2)都增加了高血压的患病风险,且存在相加交互作用。应针对打鼾与BMI≥24 kg/m^(2)的人群进行健康教育和血压监测,预防高血压等心脑血管疾病的发生。

Objective To analyze the interaction between snoring and body mass index(BMI)on hypertension,and to develop appropriate prevention strategies.Methods Based on the preliminary screening data of 82751 residents aged≥35 in the China Peace-MPP program for High-risk Cardiovascular Disease population in Jiangsu Province from September 2015 to June 2018,logistic regression analysis was used to evaluate the impact of snoring and body mass index on hypertension,and the interaction between snoring and BMI was further analyzed.Results Among the subjects,the prevalence of snorers was 45013(54.40%),hypertension was 47295(57.15%),people with BMI≥24 kg/m^(2)was 52641(63.61%).People who snored and high BMI were at higher risk for hypertension,the odds ratio(OR)was 1.686(95%CI:1.635-1.738)and 2.242(95%CI:2.172-2.313),respectively.Snoring and BMI were found to have synergistic effects on hypertension(RERI=1.160,AP=0.311,S=1.738).The risk of hypertension was 3.732 times greater when these factors both were present compared with neither was present(95%CI:3.582-3.888).Conclusions Both snoring and overweight increased the risk of hypertension,with synergistic effects.Health education and blood pressure monitoring should be carried out for people who snored and overweight to prevent the occurrence of hypertension and cardiovascular diseases.