柯萨奇病毒A组6型手足口病的流行病学研究进展

Research progress on the epidemiology of hand,foot and mouth disease caused by Coxsackievirus A6

自2008年以来,柯萨奇病毒A组6型(Coxsackievirus A6,CVA6)在全球范围内引起了多次手足口病暴发,成为引发手足口病的主要病原体之一。作为导致手足口病流行的新病原体,目前尚无预防CVA6型手足口病的有效疫苗上市。CVA6易发生重组和变异,不仅小儿易感,也可对成年人造成感染,并常引起非典型症状,如脱甲等。因此,CVA6型手足口病已成为手足口病防控的重大挑战。本文就CVA6的病原学特征及其所致的CVA6型手足口病的流行特征、影响因素及防控措施等研究进展进行综述,为CVA6型手足口病预防控制措施的制定提供科学依据。

Since 2008,outbreaks of hand,foot and mouth disease caused by Coxsackievirus A6(CVA6)were found worldwide.CVA6 has gradually become one of the predominant pathogens of hand,foot and mouth disease.As an emerging pathogen of hand,foot and mouth disease,there is no vaccine to prevent CVA6 effectively.Not only children but also adults are susceptible to CVA6,which is prone to recombination and mutation and often causes atypical symptoms,such as onychomadesis.Therefore,hand,foot and mouth disease caused by CVA6 has become a major challenge in the prevention and control of hand,foot and mouth disease.This article reviewed the research progress of its etiological and epidemic features,influencing factors,prevention and control measures of CVA6,in order to provide scientific basis for the prevention and control measures of hand,foot and mouth disease caused by CVA6.