莫家清宁丸治疗实热内结型不完全性肠梗阻的疗效观察及其对血清VIP、CRP、MTL水平的影响

Effect of Mojia Qingning Pills in treatment of incomplete intestinal obstruction of excess-heat accumulation type and its effect on serum VIP,CRP and MTL levels

目的观察莫家清宁丸治疗实热内结型不完全性肠梗阻的疗效及对血清血管活性肠肽(VIP)、C反应蛋白(CRP)、胃动素(MTL)的影响。方法选取2019年5月—2020年12月平煤神马医疗集团总医院治疗的302例实热内结型不完全性肠梗阻患者作为研究对象,按照治疗方法将全部患者分为对照组(151例)和观察组(151例)。对照组患者给予禁食水、纠正水电解质紊乱,持续胃肠减压、护胃、抗炎、解痉、镇痛等基础治疗。观察组在对照组的基础上口服莫家清宁丸,6 g/次,1次/d。两组均治疗7 d。观察两组的临床疗效和症状改善情况,同时比较两组治疗前后的VIP、CRP、MTL水平及中医证候积分。结果治疗后,对照组总有效率为80.42%,显著低于观察组的95.07%(P<0.05)。治疗后,与对照组比较,观察组腹痛缓解时间、腹胀缓解时间、首次排气时间、住院时间均明显缩短(P<0.05)。治疗后,两组血清VIP、CRP水平均明显降低,MTL水平明显升高(P<0.05);且观察组VIP、CRP水平低于对照组,MTL水平明显高于对照组(P<0.05)。治疗后,两组中医症候积分明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。结论莫家清宁丸可有效改善实热内结型不完全肠梗阻患者的临床症状,促进胃肠激水平恢复,减轻炎症水平,疗效显著。

Objective To observe the curative effect of Mojia Qingning Pills in treatment of incomplete intestinal obstruction of excess-heat accumulation type and its effect on serum VIP,CRP,and MTL.Methods A total of 302 patients with incomplete intestinal obstruction of excess-heat accumulation type treated by Pingmei Shenma Medical Group General Hospital from May 2019 to December 2020 were selected as the research subjects,and all the patients were divided into control group(151 cases)and observation group(151 cases)according to the treatment methods.Patients in the control group were given basic treatment.Patients in the observation group were po administered with Mojia Qingning Pills on the basis of control group,6 g/time,once daily.Both groups were treated for 7 d.The clinical efficacy and symptom improvement of two groups were observed,and the levels of VIP,CRP,and MTL,and TCM syndrome scores were compared before and after treatment.Results After treatment,the total effective rate of the control group was 80.42%,which was significantly lower than 95.07% of the observation group(P<0.05).After treatment,compared with the control group,the relief time of abdominal pain,the relief time of abdominal distension,the first exhaust time,and the hospitalization time in the observation group were significantly decreased(P<0.05).After treatment,the serum VIP and CRP levels in two groups were significantly decreased,while the MTL level was significantly increased(P<0.05).The levels of VIP and CRP in the observation group were lower than those in the control group,and the levels of MTL in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the scores of TCM symptoms in the two groups were significantly decreased(P<0.05),and the observation group was significantly lower than the control group(P<0.05).Conclusion Mojia Qingning Pills can effectively improve the clinical symptoms of patients with incomplete intestinal obstruction of excess-heat accumulation type,promote the recovery of gastrointestinal irritability level,reduce the level of inflammation,and have significant curative effect.