苦参碱对胃肠道疾病的药理作用研究进展

Research Progress on Pharmacologic Effect of Matrine Against Gastrointestinal Tract Diseases

苦参碱具有调节胃肠道运动和抑制结直肠推进运动的作用,以及胃肠黏膜的保护作用,能防治腹泻和结肠炎(包括溃疡性结肠炎)以及溃疡和慢性萎缩性胃炎。其作用机制与其抗氧化、抗炎和免疫调节作用有关。苦参碱还具有抗病毒和肺的保护作用。综述苦参碱对胃肠道疾病的药理作用文献,并对其研究进展做了分析。

Matrine has the effects to regulate gastrointestinal movement,and to inhibit colorectal propellant movement,and to protect on gastrointestinal mucosa. Matrine can prevent and treat diarrhea and colitis,including ulcerative colitis,and ulcer and chronic atrophic gastritis. Its mechanisms are related to antioxidation,anti-inflammation and immunoregulation. Matrine has the effects of anti-virus and pulmonoprotection too. The literatures of pharmacological effects of matrine on gastrointestinal diseases have been reviewed and their research progress has been analyzed.