热毒宁注射液与3种常用输液配伍后溶液中绿原酸与栀子苷的稳定性考察

Study on Compatible Stability of Chlorogenic Acid and Gardenoside in Solution of Reduning Injection Mixed with 3 Kinds of Common Infusion

目的:考察热毒宁注射液与3种常用输液配伍后溶液中绿原酸与栀子苷的稳定性。方法:分别将热毒宁注射液与3种常见输液(5%葡萄糖注射液、10%葡萄糖注射液和0.9%氯化钠注射液)配伍,考察其配伍液10 h内溶液pH变化情况,以及主要成分栀子苷、绿原酸的含量变化。结果:热毒宁注射液与5%葡萄糖注射液、0.9%氯化钠注射液配伍后即时(0 h),其配伍液pH值在2、4、6、8和10 h时无显著改变;热毒宁注射液与10%葡萄糖注射液配伍后2 h时,pH值也无显著改变,但在4、6、8和10 h时,其配伍液的pH值显著升高;热毒宁注射液与5%葡萄糖注射液、0.9%氯化钠注射液配伍后在2、4、6、8和10 h时,其主要成分(栀子苷、绿原酸)相对含量无显著变化;但热毒宁注射液与10%葡萄糖注射液配伍后的配伍液在4、6、8和10 h时绿原酸相对含量低于热毒宁注射液与5%葡萄糖注射液、0.9%氯化钠注射液的配伍液,提示热毒宁注射液与10%葡萄糖注射液配伍后的配伍液在10 h时绿原酸含量低于95%,而与其他两种输液配伍后其含量均在95%以上。结论:热毒宁注射液与10%葡萄糖注射液配伍后,其配伍液随时间推移pH逐渐升高,且有效成分绿原酸含量逐渐下降,临床应在配伍后4 h内使用。

Objective:To study the compatible stability of chlorogenic acid and gardenoside in the solution of Reduning injection mixed with 3 common infusions. Methods:Reduning injection was mixed with 3 common infusions(5% glucose injection, 10% glucose injection and 0.9% sodium chloride injection), respectively. The pH changes of the solutions, as well as the content changes of the main components gardenoside and chlorogenic acid in the solution were investigated within 10 h. Results:The pH value of Reduning injection, 5% glucose injection and 0.9% sodium chloride injection had no significant change at 2, 4, 6, 8 and 10 h immediately after compatibility(0 h). The pH value of Reduning injection and 10% glucose injection had no significant change at 2 h, but at 4, 6, 8 and 10 h, the pH value of the solution increased significantly. When Reduning injection was mixed with 5% glucose injection and 0.9% sodium chloride injection, the relative contents of the main components(gardenoside and chlorogenic acid) had no significant changes at2, 4, 6, 8 and 10 h. But Reduning injection with 10% glucose injection compatibility after compatibility of liquid in 4, 6,8 and 10 h below the relative contents of chlorogenic acid. Reduning injection with 5% glucose injection and 0.9% sodium chloride injection compatibility of liquid, prompt Reduning injection with 10% glucose injection compatibility after compatibility of liquid in 10 h chlorogenic acid content lower than 95%, and compatibility with other 2 infusions after its content were over 95%. Conclusions:After the compatibility of Reduning injection and 10% glucose injection, the pH of the compatibility solution increased gradually with time, and the content of chlorogenic acid, the active component, decreased gradually. It should be used within 4 h after the compatibility.