摘要
Alzheimer’s disease(AD),the most common type of dementia,is a devastating neurodegenerative disorder that seriously afflicts millions of patients and their families due to the lack of effective therapeutic drugs and methods.Elucidating the pathogenesis of this disease has always been a great challenge because AD is complicated with multiple pathophysiological features,including neurodegeneration characterized by progressive synaptic/neuronal loss leading to brain atrophy,brain Aβ deposition forming plaques,Tau hyperphosphorylation constituting neurofibrillary tangles,glial activation and neuroinflammation,and glucose hypometabolism.
基金
This research highlight was supported by the National Natural Science Foundation of China(81870822,91332201,81901081,and 81600930)
the National Key Research and Development Program of China(2016YFC1306403)
a Shanghai Municipal Science and Technology Major Project(2018SHZDZX01).