注射用哌拉西林钠舒巴坦钠治疗肺炎患者的临床效果

Clinical Effect of Piperacillin Sodium and Sulbactam Sodium for Injection on Patients with Pneumonia

目的探讨注射用哌拉西林钠舒巴坦钠治疗肺炎患者的临床效果。方法选择2016年10月至2018年8月我院收治的100例肺炎患者,随机分为观察组和对照组,每组50例。对照组患者采取注射用头孢西丁治疗,观察组患者则采取注射用哌拉西林钠舒巴坦钠治疗。比较两组的临床疗效,咳嗽症状消失时间、咳痰次数减少50%的时间、发热时间,治疗前后的白细胞计数、超敏C反应蛋白水平、白细胞介素-6水平以及不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。观察组咳嗽症状消失时间、咳痰次数减少50%的时间、发热时间均短于对照组(P<0.05)。治疗前,两组白细胞计数、超敏C反应蛋白水平、白细胞介素-6水平无差异(P>0.05);治疗后,观察组白细胞计数、超敏C反应蛋白水平、白细胞介素-6水平改善幅度较对照组更显著(P<0.05)。两组患者均无严重不良反应。结论注射用哌拉西林钠舒巴坦钠治疗肺炎患者的疗效显著,可更好的改善炎症和控制病情,缩短疗程,且不良反应少,安全性高。

Objective To explore the clinical effect of piperacillin sodium and sulbactam sodium for injection in the treatment of patients with pneumonia.Methods A total of 100 patients with pneumonia admitted to our hospital from October 2016 to August 2018 were selected and randomly divided into observation group and control group,with 50 cases in each group.Patients in the control group were treated with cefoxitin for injection,and patients in the observation group were treated with piperacillin sodium and sulbactam sodium for injection.The clinical effects,the time to disappear cough symptoms,the time to reduce the number of sputum by 50%,the time to fever of the two groups were compared,the white blood cell count,the level of high-sensitivity C-reactive protein,the level of interleukin-6,and the occurrence of adverse reactions before and after treatment.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).The time to disappear cough symptoms,the time to reduce the number of sputum by 50%,and the time of fever in the observation group were shorter than those in the control group(P<0.05).Before treatment,the white blood cell count,high-sensitivity C-reactive protein level,and interleukin-6 level of the two groups were no statistically significant(P>0.05);after treatment,the observation group’s white blood cell count,high-sensitivity C-reactive protein level,white blood cell the improvement of interleukin-6 level was more significant than that of the control group(P<0.05).There were no serious adverse reactions in both groups.Conclusion Piperacillin sodium and sulbactam sodium for injection has a significant effect on patients with pneumonia,which can better improve inflammation and control the condition,shorten the course of treatment,and have fewer adverse reactions and high safety.